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Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.

Publication ,  Journal Article
Shelburne, JD; Arstila, AU; Trump, BF
Published in: Am J Pathol
September 1973

Intraperitoneal injections of either cyclic AMP or dibutyryl cyclic AMP are capable of producing a wave of autophagy in rat liver which resembles closely that stimulated by glucagon. These autophagic vacuoles are acid-phosphatase-positive and appear to arise via the envelopment of organelles by double-walled cisterna. At later times these autophagic vacuoles are usually surrounded by a single membrane. Injection of equimolar amounts of 5'-AMP failed to produce a wave of autophagy. These findings constitute preliminary evidence that glucagon-stimulated autophagy is mediated at least in part by cyclic AMP.

Duke Scholars

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

September 1973

Volume

72

Issue

3

Start / End Page

521 / 540

Location

United States

Related Subject Headings

  • Time Factors
  • Staining and Labeling
  • Sodium Chloride
  • Rats
  • Phagocytosis
  • Pathology
  • Mitochondria
  • Microscopy, Electron
  • Liver Glycogen
  • Liver
 

Citation

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Chicago
ICMJE
MLA
NLM
Shelburne, J. D., Arstila, A. U., & Trump, B. F. (1973). Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver. Am J Pathol, 72(3), 521–540.
Shelburne, J. D., A. U. Arstila, and B. F. Trump. “Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.Am J Pathol 72, no. 3 (September 1973): 521–40.
Shelburne JD, Arstila AU, Trump BF. Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver. Am J Pathol. 1973 Sep;72(3):521–40.
Shelburne, J. D., et al. “Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.Am J Pathol, vol. 72, no. 3, Sept. 1973, pp. 521–40.
Shelburne JD, Arstila AU, Trump BF. Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver. Am J Pathol. 1973 Sep;72(3):521–540.
Journal cover image

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

September 1973

Volume

72

Issue

3

Start / End Page

521 / 540

Location

United States

Related Subject Headings

  • Time Factors
  • Staining and Labeling
  • Sodium Chloride
  • Rats
  • Phagocytosis
  • Pathology
  • Mitochondria
  • Microscopy, Electron
  • Liver Glycogen
  • Liver