Skip to main content
Journal cover image

Hemidesmosome-like intercellular specializations in human meningiomas.

Publication ,  Journal Article
Copeland, DD; Bell, SW; Shelburne, JD
Published in: Cancer
June 1978

Desmosomes, gap junctions and tight junctions are intercellular specializations which have been described in human meningiomas. We report, in five of five meningiomas, including a pulmonary metastasis from a malignant intracranial meningioma, a fourth type of intercellular specialization which is similar to but not identical with the hemidesmosome of the epidermis. Idential intercellular specializations have been described between arachnoidal cells, but not between dural fibroblasts. The presence of the junction in human meningeal neoplasms of diverse histologic pattern supports the origin of the meningioma from arachnoidal epithelium. The consistent occurrence of these structures in a pulmonary metastasis as well as benign intracranial tumors suggests that they may be a useful morphologic marker in the differential diagnosis of putative extracranial metastatic meningiomas.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

June 1978

Volume

41

Issue

6

Start / End Page

2242 / 2249

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Middle Aged
  • Microscopy, Electron
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Lung Neoplasms
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Copeland, D. D., Bell, S. W., & Shelburne, J. D. (1978). Hemidesmosome-like intercellular specializations in human meningiomas. Cancer, 41(6), 2242–2249. https://doi.org/10.1002/1097-0142(197806)41:6<2242::aid-cncr2820410625>3.0.co;2-u
Copeland, D. D., S. W. Bell, and J. D. Shelburne. “Hemidesmosome-like intercellular specializations in human meningiomas.Cancer 41, no. 6 (June 1978): 2242–49. https://doi.org/10.1002/1097-0142(197806)41:6<2242::aid-cncr2820410625>3.0.co;2-u.
Copeland DD, Bell SW, Shelburne JD. Hemidesmosome-like intercellular specializations in human meningiomas. Cancer. 1978 Jun;41(6):2242–9.
Copeland, D. D., et al. “Hemidesmosome-like intercellular specializations in human meningiomas.Cancer, vol. 41, no. 6, June 1978, pp. 2242–49. Pubmed, doi:10.1002/1097-0142(197806)41:6<2242::aid-cncr2820410625>3.0.co;2-u.
Copeland DD, Bell SW, Shelburne JD. Hemidesmosome-like intercellular specializations in human meningiomas. Cancer. 1978 Jun;41(6):2242–2249.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

June 1978

Volume

41

Issue

6

Start / End Page

2242 / 2249

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Middle Aged
  • Microscopy, Electron
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Lung Neoplasms
  • Humans
  • Female