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Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.

Publication ,  Journal Article
Cruz, MC; Sia, RA; Olson, M; Cox, GM; Heitman, J
Published in: Infect Immun
February 2000

The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.

Duke Scholars

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

February 2000

Volume

68

Issue

2

Start / End Page

982 / 985

Location

United States

Related Subject Headings

  • Virulence
  • Serotyping
  • Mutation
  • Molecular Sequence Data
  • Microbiology
  • Mice, Inbred BALB C
  • Mice
  • Cryptococcus neoformans
  • Calcineurin
  • Base Sequence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cruz, M. C., Sia, R. A., Olson, M., Cox, G. M., & Heitman, J. (2000). Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. Infect Immun, 68(2), 982–985. https://doi.org/10.1128/IAI.68.2.982-985.2000
Cruz, M. C., R. A. Sia, M. Olson, G. M. Cox, and J. Heitman. “Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.Infect Immun 68, no. 2 (February 2000): 982–85. https://doi.org/10.1128/IAI.68.2.982-985.2000.
Cruz, M. C., et al. “Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.Infect Immun, vol. 68, no. 2, Feb. 2000, pp. 982–85. Pubmed, doi:10.1128/IAI.68.2.982-985.2000.

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

February 2000

Volume

68

Issue

2

Start / End Page

982 / 985

Location

United States

Related Subject Headings

  • Virulence
  • Serotyping
  • Mutation
  • Molecular Sequence Data
  • Microbiology
  • Mice, Inbred BALB C
  • Mice
  • Cryptococcus neoformans
  • Calcineurin
  • Base Sequence