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Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients.

Publication ,  Journal Article
Grichnik, JM; Crawford, J; Jimenez, F; Kurtzberg, J; Buchanan, M; Blackwell, S; Clark, RE; Hitchcock, MG
Published in: J Am Acad Dermatol
October 1995

BACKGROUND: Recombinant human stem-cell factor (SCF), a cytokine acting on hematopoietic progenitor cells, has potential for the treatment of several hematologic and oncologic disorders. In a hematology-oncology phase I trial of SCF, several patients had cutaneous hyperpigmentation at the SCF subcutaneous injection sites. OBJECTIVE: Our purpose was to investigate the pathogenesis of this hyperpigmentation phenomenon. METHODS: Skin biopsy specimens were obtained before, at the completion of, and after SCF therapy and were processed for histology, immunohistology, and electron microscopy. RESULTS: Skin at the site of SCF injection had an increased number of melanocytes, increased melanocytic dendrite extension, and melanin as compared with noninjected tissue. Immunohistochemical stains revealed an increase in staining with melanocyte-specific monoclonal antibodies HMB-45 and NKI/beteb, and a monoclonal antibody to the receptor for SCF, c-kit. CONCLUSION: Subcutaneous injection of SCF results in hyperplasia of melanocytes. SCF may be useful in the treatment of melanocytopenic disorders, but caution may be necessary in patients with disorders of melanocyte proliferation.

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Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

October 1995

Volume

33

Issue

4

Start / End Page

577 / 583

Location

United States

Related Subject Headings

  • Stem Cell Factor
  • Recombinant Proteins
  • Melanocytes
  • Melanins
  • Lung Neoplasms
  • Injections, Subcutaneous
  • Hyperplasia
  • Hyperpigmentation
  • Humans
  • Hematopoietic Cell Growth Factors
 

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Grichnik, J. M., Crawford, J., Jimenez, F., Kurtzberg, J., Buchanan, M., Blackwell, S., … Hitchcock, M. G. (1995). Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. J Am Acad Dermatol, 33(4), 577–583. https://doi.org/10.1016/0190-9622(95)91274-6
Grichnik, J. M., J. Crawford, F. Jimenez, J. Kurtzberg, M. Buchanan, S. Blackwell, R. E. Clark, and M. G. Hitchcock. “Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients.J Am Acad Dermatol 33, no. 4 (October 1995): 577–83. https://doi.org/10.1016/0190-9622(95)91274-6.
Grichnik JM, Crawford J, Jimenez F, Kurtzberg J, Buchanan M, Blackwell S, et al. Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. J Am Acad Dermatol. 1995 Oct;33(4):577–83.
Grichnik, J. M., et al. “Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients.J Am Acad Dermatol, vol. 33, no. 4, Oct. 1995, pp. 577–83. Pubmed, doi:10.1016/0190-9622(95)91274-6.
Grichnik JM, Crawford J, Jimenez F, Kurtzberg J, Buchanan M, Blackwell S, Clark RE, Hitchcock MG. Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. J Am Acad Dermatol. 1995 Oct;33(4):577–583.
Journal cover image

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

October 1995

Volume

33

Issue

4

Start / End Page

577 / 583

Location

United States

Related Subject Headings

  • Stem Cell Factor
  • Recombinant Proteins
  • Melanocytes
  • Melanins
  • Lung Neoplasms
  • Injections, Subcutaneous
  • Hyperplasia
  • Hyperpigmentation
  • Humans
  • Hematopoietic Cell Growth Factors