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Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature.

Publication ,  Journal Article
Hilden, JM; Watterson, J; Longee, DC; Moertel, CL; Dunn, ME; Kurtzberg, J; Scheithauer, BW
Published in: J Neurooncol
December 1998

Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than 12 months after diagnosis. Intensified therapy has been recently used for children with this disease, with promising results [1,2]. We report four cases of ATT/RT in young children; all had subtotal resections and localized disease at diagnosis. One child treated prior to bone marrow transplant availability died of progressive disease 9 months after diagnosis. Another child, treated with high-dose chemotherapy and radiotherapy in preparation for bone marrow transplant, had a recurrence and died 20 months after diagnosis, without undergoing the transplant. Two children received high-dose chemotherapy and autologous bone-marrow transplant and had a good response to treatment; one survived 19 months, the other child is free of disease 46 months from diagnosis. Intensified therapy has altered the natural history of central nervous system ATT/RT.

Duke Scholars

Published In

J Neurooncol

DOI

ISSN

0167-594X

Publication Date

December 1998

Volume

40

Issue

3

Start / End Page

265 / 275

Location

United States

Related Subject Headings

  • Teratoma
  • Survival Analysis
  • Rhabdoid Tumor
  • Oncology & Carcinogenesis
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Female
  • Fatal Outcome
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hilden, J. M., Watterson, J., Longee, D. C., Moertel, C. L., Dunn, M. E., Kurtzberg, J., & Scheithauer, B. W. (1998). Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature. J Neurooncol, 40(3), 265–275. https://doi.org/10.1023/a:1006125120866
Hilden, J. M., J. Watterson, D. C. Longee, C. L. Moertel, M. E. Dunn, J. Kurtzberg, and B. W. Scheithauer. “Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature.J Neurooncol 40, no. 3 (December 1998): 265–75. https://doi.org/10.1023/a:1006125120866.
Hilden JM, Watterson J, Longee DC, Moertel CL, Dunn ME, Kurtzberg J, et al. Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature. J Neurooncol. 1998 Dec;40(3):265–75.
Hilden, J. M., et al. “Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature.J Neurooncol, vol. 40, no. 3, Dec. 1998, pp. 265–75. Pubmed, doi:10.1023/a:1006125120866.
Hilden JM, Watterson J, Longee DC, Moertel CL, Dunn ME, Kurtzberg J, Scheithauer BW. Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature. J Neurooncol. 1998 Dec;40(3):265–275.
Journal cover image

Published In

J Neurooncol

DOI

ISSN

0167-594X

Publication Date

December 1998

Volume

40

Issue

3

Start / End Page

265 / 275

Location

United States

Related Subject Headings

  • Teratoma
  • Survival Analysis
  • Rhabdoid Tumor
  • Oncology & Carcinogenesis
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Female
  • Fatal Outcome