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Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome.

Publication ,  Journal Article
Keller, FG; Kurtzberg, J
Published in: Am J Pediatr Hematol Oncol
November 1994

PURPOSE: We report a case of infection-associated hemophagocytic syndrome in the setting of disseminated histoplasmosis. PATIENTS AND METHODS: A 6-year-old boy with chronic mucocutaneous candidiasis developed a fulminant hemophagocytic syndrome. Evaluation for an infectious cause included bacterial, mycobacterial, viral, and fungal cultures, serological assessment, and histological examination of bone marrow and bronchoalveolar lavage fluid. RESULTS: Culture of bone marrow aspirate, blood, and bronchoalveolar lavage showed disseminated histoplasmosis as the cause for this patient's hemophagocytic syndrome. The patient was treated with amphotericin B with complete resolution of his hemophagocytic syndrome. CONCLUSIONS: Disseminated histoplasmosis is another cause of IAHS in children with an underlying immunodeficiency. Diagnostic difficulties associated with the hemophagocytic syndromes of childhood are discussed.

Duke Scholars

Published In

Am J Pediatr Hematol Oncol

ISSN

0192-8562

Publication Date

November 1994

Volume

16

Issue

4

Start / End Page

368 / 371

Location

United States

Related Subject Headings

  • Phagocytosis
  • Male
  • Humans
  • Histoplasmosis
  • Histiocytosis, Non-Langerhans-Cell
  • Child
  • Bone Marrow
 

Citation

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ICMJE
MLA
NLM
Keller, F. G., & Kurtzberg, J. (1994). Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. Am J Pediatr Hematol Oncol, 16(4), 368–371.
Keller, F. G., and J. Kurtzberg. “Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome.Am J Pediatr Hematol Oncol 16, no. 4 (November 1994): 368–71.
Keller FG, Kurtzberg J. Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. Am J Pediatr Hematol Oncol. 1994 Nov;16(4):368–71.
Keller, F. G., and J. Kurtzberg. “Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome.Am J Pediatr Hematol Oncol, vol. 16, no. 4, Nov. 1994, pp. 368–71.
Keller FG, Kurtzberg J. Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome. Am J Pediatr Hematol Oncol. 1994 Nov;16(4):368–371.

Published In

Am J Pediatr Hematol Oncol

ISSN

0192-8562

Publication Date

November 1994

Volume

16

Issue

4

Start / End Page

368 / 371

Location

United States

Related Subject Headings

  • Phagocytosis
  • Male
  • Humans
  • Histoplasmosis
  • Histiocytosis, Non-Langerhans-Cell
  • Child
  • Bone Marrow