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Cisplatinum-induced renal salt wasting.

Publication ,  Journal Article
Kurtzberg, J; Dennis, VW; Kinney, TR
Published in: Med Pediatr Oncol
1984

We report two patients who developed high urinary excretion of sodium chloride after receiving cisplatinum. One patient became symptomatically hyponatremic during intravenous administration of hypotonic fluid. The second patient developed orthostatic hypotension. Urine sodium and chloride concentrations exceeded 130 mmol/liter despite hyponatremia or volume depletion. There was no evidence of adrenal cortical impairment and no improvement with fludrocortisone. We propose that cisplatinum may inhibit solute transport by the thick ascending limb of Henle, causing clinically significant, previously unreported toxicity in patients receiving chronic cisplatinum antitumor therapy.

Duke Scholars

Published In

Med Pediatr Oncol

DOI

ISSN

0098-1532

Publication Date

1984

Volume

12

Issue

2

Start / End Page

150 / 154

Location

United States

Related Subject Headings

  • Sodium Chloride
  • Oncology & Carcinogenesis
  • Natriuresis
  • Male
  • Kidney
  • Hyponatremia
  • Humans
  • Female
  • Cisplatin
  • Child, Preschool
 

Citation

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MLA
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Kurtzberg, J., Dennis, V. W., & Kinney, T. R. (1984). Cisplatinum-induced renal salt wasting. Med Pediatr Oncol, 12(2), 150–154. https://doi.org/10.1002/mpo.2950120219
Kurtzberg, J., V. W. Dennis, and T. R. Kinney. “Cisplatinum-induced renal salt wasting.Med Pediatr Oncol 12, no. 2 (1984): 150–54. https://doi.org/10.1002/mpo.2950120219.
Kurtzberg J, Dennis VW, Kinney TR. Cisplatinum-induced renal salt wasting. Med Pediatr Oncol. 1984;12(2):150–4.
Kurtzberg, J., et al. “Cisplatinum-induced renal salt wasting.Med Pediatr Oncol, vol. 12, no. 2, 1984, pp. 150–54. Pubmed, doi:10.1002/mpo.2950120219.
Kurtzberg J, Dennis VW, Kinney TR. Cisplatinum-induced renal salt wasting. Med Pediatr Oncol. 1984;12(2):150–154.

Published In

Med Pediatr Oncol

DOI

ISSN

0098-1532

Publication Date

1984

Volume

12

Issue

2

Start / End Page

150 / 154

Location

United States

Related Subject Headings

  • Sodium Chloride
  • Oncology & Carcinogenesis
  • Natriuresis
  • Male
  • Kidney
  • Hyponatremia
  • Humans
  • Female
  • Cisplatin
  • Child, Preschool