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Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.

Publication ,  Journal Article
Kurtzberg, J; Carter, SG
Published in: Exp Hematol
November 1990

We have studied the in vitro effects of carbovir as compared to 3'-azido-3'-deoxythymidine (AZT) on the growth of clonal bone marrow-derived hematopoietic progenitor cells. (-)Carbovir, the enantiomer with anti-human immunodeficiency virus (HIV) activity, exhibited significantly less toxicity to hematopoietic cells than AZT. These in vitro studies suggest that (-)carbovir will exhibit less hematologic toxicity in the therapy of patients infected with HIV either as a single agent or in combination with other agents that inhibit HIV proliferation.

Duke Scholars

Published In

Exp Hematol

ISSN

0301-472X

Publication Date

November 1990

Volume

18

Issue

10

Start / End Page

1094 / 1096

Location

Netherlands

Related Subject Headings

  • Zidovudine
  • Megakaryocytes
  • Macrophages
  • Immunology
  • Humans
  • Hematopoietic Stem Cells
  • Granulocytes
  • Erythroid Precursor Cells
  • Dose-Response Relationship, Drug
  • Dideoxynucleosides
 

Citation

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MLA
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Kurtzberg, J., & Carter, S. G. (1990). Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro. Exp Hematol, 18(10), 1094–1096.
Kurtzberg, J., and S. G. Carter. “Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.Exp Hematol 18, no. 10 (November 1990): 1094–96.
Kurtzberg, J., and S. G. Carter. “Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.Exp Hematol, vol. 18, no. 10, Nov. 1990, pp. 1094–96.
Journal cover image

Published In

Exp Hematol

ISSN

0301-472X

Publication Date

November 1990

Volume

18

Issue

10

Start / End Page

1094 / 1096

Location

Netherlands

Related Subject Headings

  • Zidovudine
  • Megakaryocytes
  • Macrophages
  • Immunology
  • Humans
  • Hematopoietic Stem Cells
  • Granulocytes
  • Erythroid Precursor Cells
  • Dose-Response Relationship, Drug
  • Dideoxynucleosides