Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.
Publication
, Journal Article
Kurtzberg, J; Carter, SG
Published in: Exp Hematol
November 1990
We have studied the in vitro effects of carbovir as compared to 3'-azido-3'-deoxythymidine (AZT) on the growth of clonal bone marrow-derived hematopoietic progenitor cells. (-)Carbovir, the enantiomer with anti-human immunodeficiency virus (HIV) activity, exhibited significantly less toxicity to hematopoietic cells than AZT. These in vitro studies suggest that (-)carbovir will exhibit less hematologic toxicity in the therapy of patients infected with HIV either as a single agent or in combination with other agents that inhibit HIV proliferation.
Duke Scholars
Published In
Exp Hematol
ISSN
0301-472X
Publication Date
November 1990
Volume
18
Issue
10
Start / End Page
1094 / 1096
Location
Netherlands
Related Subject Headings
- Zidovudine
- Megakaryocytes
- Macrophages
- Immunology
- Humans
- Hematopoietic Stem Cells
- Granulocytes
- Erythroid Precursor Cells
- Dose-Response Relationship, Drug
- Dideoxynucleosides
Citation
APA
Chicago
ICMJE
MLA
NLM
Kurtzberg, J., & Carter, S. G. (1990). Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro. Exp Hematol, 18(10), 1094–1096.
Kurtzberg, J., and S. G. Carter. “Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.” Exp Hematol 18, no. 10 (November 1990): 1094–96.
Kurtzberg J, Carter SG. Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro. Exp Hematol. 1990 Nov;18(10):1094–6.
Kurtzberg, J., and S. G. Carter. “Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro.” Exp Hematol, vol. 18, no. 10, Nov. 1990, pp. 1094–96.
Kurtzberg J, Carter SG. Differential toxicity of carbovir and AZT to human bone marrow hematopoietic progenitor cells in vitro. Exp Hematol. 1990 Nov;18(10):1094–1096.
Published In
Exp Hematol
ISSN
0301-472X
Publication Date
November 1990
Volume
18
Issue
10
Start / End Page
1094 / 1096
Location
Netherlands
Related Subject Headings
- Zidovudine
- Megakaryocytes
- Macrophages
- Immunology
- Humans
- Hematopoietic Stem Cells
- Granulocytes
- Erythroid Precursor Cells
- Dose-Response Relationship, Drug
- Dideoxynucleosides