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Rectal mucosal ornithine decarboxylase activity is not a useful marker of risk for colorectal neoplasia.

Publication ,  Journal Article
Sandler, RS; Ulshen, MH; Lyles, CM; McAuliffe, CA; Fuller, CR
Published in: Dig Dis Sci
November 1992

Rectal mucosal ornithine decarboxylase activity has been reported to distinguish patients with adenomas from normal controls. In order to further explore this association, we assayed biopsy samples from 119 unselected individuals undergoing routine colonoscopic examinations. The overall mean ODC activity was 127.4 (+/- 93.1 SD) pmol/mg protein/hr. There were no differences by age, sex, or race. Tissue handling and storage influenced ODC activity. Specimens collected and transported on Dry Ice had higher ODC activity than specimens initially frozen in a -20 degrees C freezer. After adjusting for storage and collection method, the activity was similar in subjects with adenomas (126.3 pmol/mg/hr) compared to those without adenomas (128.8 pmol/mg/hr). We conclude that variations in assay technique make comparisons between laboratories difficult. Patients with large-bowel adenomas do not necessarily have higher ODC activity in uninvolved rectal mucosa. Further study of the environmental and genetic factors that influence rectal mucosal proliferation may improve our understanding of carcinogenesis in the large bowel.

Duke Scholars

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

November 1992

Volume

37

Issue

11

Start / End Page

1718 / 1724

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Rectum
  • Ornithine Decarboxylase
  • North Carolina
  • Middle Aged
  • Male
  • Intestinal Mucosa
  • Humans
  • Gastroenterology & Hepatology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sandler, R. S., Ulshen, M. H., Lyles, C. M., McAuliffe, C. A., & Fuller, C. R. (1992). Rectal mucosal ornithine decarboxylase activity is not a useful marker of risk for colorectal neoplasia. Dig Dis Sci, 37(11), 1718–1724. https://doi.org/10.1007/BF01299865
Sandler, R. S., M. H. Ulshen, C. M. Lyles, C. A. McAuliffe, and C. R. Fuller. “Rectal mucosal ornithine decarboxylase activity is not a useful marker of risk for colorectal neoplasia.Dig Dis Sci 37, no. 11 (November 1992): 1718–24. https://doi.org/10.1007/BF01299865.
Sandler RS, Ulshen MH, Lyles CM, McAuliffe CA, Fuller CR. Rectal mucosal ornithine decarboxylase activity is not a useful marker of risk for colorectal neoplasia. Dig Dis Sci. 1992 Nov;37(11):1718–24.
Sandler, R. S., et al. “Rectal mucosal ornithine decarboxylase activity is not a useful marker of risk for colorectal neoplasia.Dig Dis Sci, vol. 37, no. 11, Nov. 1992, pp. 1718–24. Pubmed, doi:10.1007/BF01299865.
Sandler RS, Ulshen MH, Lyles CM, McAuliffe CA, Fuller CR. Rectal mucosal ornithine decarboxylase activity is not a useful marker of risk for colorectal neoplasia. Dig Dis Sci. 1992 Nov;37(11):1718–1724.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

November 1992

Volume

37

Issue

11

Start / End Page

1718 / 1724

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Rectum
  • Ornithine Decarboxylase
  • North Carolina
  • Middle Aged
  • Male
  • Intestinal Mucosa
  • Humans
  • Gastroenterology & Hepatology