An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)
Publication
, Journal Article
Aslanian, R; Lee, G; Iyer, RV; Shih, NY; Piwinski, JJ; Draper, RW; McPhail, AT
Published in: Tetrahedron Asymmetry
October 6, 2000
A short, high yielding, enantioselective synthesis of the novel H3 agonist Sch 50971 1 is described. The key enantiodifferentiating step is the 1,4-addition of a chiral N-propionyloxazolidinone to a nitroolefin. Copyright (C) 2000 Elsevier Science Ltd.
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Published In
Tetrahedron Asymmetry
DOI
ISSN
0957-4166
Publication Date
October 6, 2000
Volume
11
Issue
19
Start / End Page
3867 / 3871
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 0305 Organic Chemistry
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Aslanian, R., Lee, G., Iyer, R. V., Shih, N. Y., Piwinski, J. J., Draper, R. W., & McPhail, A. T. (2000). An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971). Tetrahedron Asymmetry, 11(19), 3867–3871. https://doi.org/10.1016/S0957-4166(00)00380-3
Aslanian, R., G. Lee, R. V. Iyer, N. Y. Shih, J. J. Piwinski, R. W. Draper, and A. T. McPhail. “An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971).” Tetrahedron Asymmetry 11, no. 19 (October 6, 2000): 3867–71. https://doi.org/10.1016/S0957-4166(00)00380-3.
Aslanian R, Lee G, Iyer RV, Shih NY, Piwinski JJ, Draper RW, et al. An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971). Tetrahedron Asymmetry. 2000 Oct 6;11(19):3867–71.
Aslanian, R., et al. “An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971).” Tetrahedron Asymmetry, vol. 11, no. 19, Oct. 2000, pp. 3867–71. Scopus, doi:10.1016/S0957-4166(00)00380-3.
Aslanian R, Lee G, Iyer RV, Shih NY, Piwinski JJ, Draper RW, McPhail AT. An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971). Tetrahedron Asymmetry. 2000 Oct 6;11(19):3867–3871.
Published In
Tetrahedron Asymmetry
DOI
ISSN
0957-4166
Publication Date
October 6, 2000
Volume
11
Issue
19
Start / End Page
3867 / 3871
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 0305 Organic Chemistry