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Boranophosphates as mimics of natural phosphodiesters in DNA.

Publication ,  Journal Article
Summers, JS; Shaw, BR
Published in: Current medicinal chemistry
August 2001

In boranophosphate-oligodeoxynucleosides (BH(3)(-)-ODN) a borane group replaces one of the two non-bridging oxygen atoms in the phosphodiester backbone of the naturally occurring congener. The chemical and biophysical properties of BH(3)(-) ODN are reviewed, as are their interactions with enzymes such as DNA polymerases, exo- and endonucleases, and ribonuclease H. Three approaches to synthesis of BH3- ODN are described: in solution, on solid supports, and by template directed enzymatic polymerization of appropriately modified nucleoside triphosphates. Comparisons are made to other members of the family of phosphorus modified nucleic acids, the phosphorothioates and methyl phos phonates. The potential applications of boranophosphate modified compounds to antisense therapeutics and DNA sequencing are discussed.

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Published In

Current medicinal chemistry

DOI

EISSN

1875-533X

ISSN

0929-8673

Publication Date

August 2001

Volume

8

Issue

10

Start / End Page

1147 / 1155

Related Subject Headings

  • Sequence Analysis, DNA
  • Ribonuclease H
  • Phosphates
  • Oligonucleotides, Antisense
  • Oligodeoxyribonucleotides
  • Nucleic Acid Conformation
  • Molecular Conformation
  • Medicinal & Biomolecular Chemistry
  • Enzyme Activation
  • Deoxyribonucleases
 

Citation

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Summers, J. S., & Shaw, B. R. (2001). Boranophosphates as mimics of natural phosphodiesters in DNA. Current Medicinal Chemistry, 8(10), 1147–1155. https://doi.org/10.2174/0929867013372409
Summers, J. S., and B. R. Shaw. “Boranophosphates as mimics of natural phosphodiesters in DNA.Current Medicinal Chemistry 8, no. 10 (August 2001): 1147–55. https://doi.org/10.2174/0929867013372409.
Summers JS, Shaw BR. Boranophosphates as mimics of natural phosphodiesters in DNA. Current medicinal chemistry. 2001 Aug;8(10):1147–55.
Summers, J. S., and B. R. Shaw. “Boranophosphates as mimics of natural phosphodiesters in DNA.Current Medicinal Chemistry, vol. 8, no. 10, Aug. 2001, pp. 1147–55. Epmc, doi:10.2174/0929867013372409.
Summers JS, Shaw BR. Boranophosphates as mimics of natural phosphodiesters in DNA. Current medicinal chemistry. 2001 Aug;8(10):1147–1155.

Published In

Current medicinal chemistry

DOI

EISSN

1875-533X

ISSN

0929-8673

Publication Date

August 2001

Volume

8

Issue

10

Start / End Page

1147 / 1155

Related Subject Headings

  • Sequence Analysis, DNA
  • Ribonuclease H
  • Phosphates
  • Oligonucleotides, Antisense
  • Oligodeoxyribonucleotides
  • Nucleic Acid Conformation
  • Molecular Conformation
  • Medicinal & Biomolecular Chemistry
  • Enzyme Activation
  • Deoxyribonucleases