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Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria.

Publication ,  Journal Article
Holmgren, A; Kuehn, MJ; Brändén, CI; Hultgren, SJ
Published in: EMBO J
April 1992

Detailed structural analyses revealed a family of periplasmic chaperones in Gram-negative prokaryotes which are structurally and possibly evolutionarily related to the immunoglobulin superfamily and assist in the assembly of adhesive pili. The members of this family have similar structures consistent with the overall topology of an immunoglobulin fold. Seven pilus chaperone sequences from Escherichia coli, Haemophilus influenzae and Klebsiella pneumoniae were aligned and their consensus sequence was superimposed onto the known three-dimensional structure of PapD, a representative member of the family. The molecular details of the conserved and variable structural motifs in this family of periplasmic chaperones give important insight into their structure, function, mechanism of action and evolutionary relationship with the immunoglobulin superfamily.

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Published In

EMBO J

DOI

ISSN

0261-4189

Publication Date

April 1992

Volume

11

Issue

4

Start / End Page

1617 / 1622

Location

England

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Protein Conformation
  • Multigene Family
  • Molecular Sequence Data
  • Models, Molecular
  • Klebsiella pneumoniae
  • Immunoglobulins
  • Hemagglutinins
  • Haemophilus influenzae
  • Escherichia coli
 

Citation

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MLA
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Holmgren, A., Kuehn, M. J., Brändén, C. I., & Hultgren, S. J. (1992). Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. EMBO J, 11(4), 1617–1622. https://doi.org/10.1002/j.1460-2075.1992.tb05207.x
Holmgren, A., M. J. Kuehn, C. I. Brändén, and S. J. Hultgren. “Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria.EMBO J 11, no. 4 (April 1992): 1617–22. https://doi.org/10.1002/j.1460-2075.1992.tb05207.x.
Holmgren A, Kuehn MJ, Brändén CI, Hultgren SJ. Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. EMBO J. 1992 Apr;11(4):1617–22.
Holmgren, A., et al. “Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria.EMBO J, vol. 11, no. 4, Apr. 1992, pp. 1617–22. Pubmed, doi:10.1002/j.1460-2075.1992.tb05207.x.
Holmgren A, Kuehn MJ, Brändén CI, Hultgren SJ. Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. EMBO J. 1992 Apr;11(4):1617–1622.

Published In

EMBO J

DOI

ISSN

0261-4189

Publication Date

April 1992

Volume

11

Issue

4

Start / End Page

1617 / 1622

Location

England

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Protein Conformation
  • Multigene Family
  • Molecular Sequence Data
  • Models, Molecular
  • Klebsiella pneumoniae
  • Immunoglobulins
  • Hemagglutinins
  • Haemophilus influenzae
  • Escherichia coli