Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.
Publication
, Journal Article
Kavanagh, BD; Halperin, EC; Rosenbaum, LC; Shannon, EM; Nilaver, G
Published in: Cancer
March 15, 1992
A patient with a primary undifferentiated carcinoma of the nasopharynx manifested the clinical syndrome of inappropriate antidiuretic hormone secretion (SIADH). Immunohistochemical techniques demonstrated the presence of vasopressin, neurophysin, and their precursor (propressophysin) in the cancer cells. In situ hybridization additionally confirmed the expression of propressophysin messenger RNA in these cells. To the knowledge of the authors, this represents not only the first case of SIADH caused by carcinoma of the nasopharynx, but also the first report of pathologic confirmation of the syndrome with the use of both molecular and immunologic probes.
Duke Scholars
Published In
Cancer
DOI
ISSN
0008-543X
Publication Date
March 15, 1992
Volume
69
Issue
6
Start / End Page
1315 / 1319
Location
United States
Related Subject Headings
- Vasopressins
- Protein Precursors
- Oxytocin
- Oncology & Carcinogenesis
- Nucleic Acid Hybridization
- Neurophysins
- Nasopharyngeal Neoplasms
- Middle Aged
- Male
- Inappropriate ADH Syndrome
Citation
APA
Chicago
ICMJE
MLA
NLM
Kavanagh, B. D., Halperin, E. C., Rosenbaum, L. C., Shannon, E. M., & Nilaver, G. (1992). Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx. Cancer, 69(6), 1315–1319. https://doi.org/10.1002/1097-0142(19920315)69:6<1315::aid-cncr2820690602>3.0.co;2-2
Kavanagh, B. D., E. C. Halperin, L. C. Rosenbaum, E. M. Shannon, and G. Nilaver. “Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.” Cancer 69, no. 6 (March 15, 1992): 1315–19. https://doi.org/10.1002/1097-0142(19920315)69:6<1315::aid-cncr2820690602>3.0.co;2-2.
Kavanagh BD, Halperin EC, Rosenbaum LC, Shannon EM, Nilaver G. Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx. Cancer. 1992 Mar 15;69(6):1315–9.
Kavanagh, B. D., et al. “Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.” Cancer, vol. 69, no. 6, Mar. 1992, pp. 1315–19. Pubmed, doi:10.1002/1097-0142(19920315)69:6<1315::aid-cncr2820690602>3.0.co;2-2.
Kavanagh BD, Halperin EC, Rosenbaum LC, Shannon EM, Nilaver G. Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx. Cancer. 1992 Mar 15;69(6):1315–1319.
Published In
Cancer
DOI
ISSN
0008-543X
Publication Date
March 15, 1992
Volume
69
Issue
6
Start / End Page
1315 / 1319
Location
United States
Related Subject Headings
- Vasopressins
- Protein Precursors
- Oxytocin
- Oncology & Carcinogenesis
- Nucleic Acid Hybridization
- Neurophysins
- Nasopharyngeal Neoplasms
- Middle Aged
- Male
- Inappropriate ADH Syndrome