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Treatment of iron deficiency anemia: are monomeric iron compounds suitable for parenteral administration?

Publication ,  Journal Article
Gupta, A; Crumbliss, AL
Published in: The Journal of laboratory and clinical medicine
November 2000

Iron deficiency is the most common nutritional problem worldwide, especially in the developing countries. Oral iron supplementation programs have failed because of noncompliance and gastrointestinal toxicity, thereby necessitating parenteral administration of iron. For parenteral administration, only iron-carbohydrate complexes are currently used, because monomeric iron salts release free iron, thereby causing oxidant injury. However, iron-carbohydrate complexes also have significant toxicity, and they are expensive. We have proposed the hypothesis that monomeric iron salts can be safely administered by the parenteral route if iron is tightly complexed to the ligand, thereby causing clinically insignificant release of free iron, and the kinetic properties of the compound allow rapid transfer of iron to plasma transferrin. A detailed analysis of the physicochemical and kinetic properties reveals that ferric iron complexed to pyrophosphate or acetohydroxamate anions may be suitable for parenteral administration. We have demonstrated that infusion of ferric pyrophosphate into the circulation via the dialysate is safe and effective in maintaining iron balance in patients undergoing maintenance hemodialysis. Parenteral administration of monomeric iron compounds is a promising approach to the treatment of iron deficiency in the general population and merits further investigation.

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Published In

The Journal of laboratory and clinical medicine

DOI

EISSN

1532-6543

ISSN

0022-2143

Publication Date

November 2000

Volume

136

Issue

5

Start / End Page

371 / 378

Related Subject Headings

  • Iron
  • Injections
  • Humans
  • General Clinical Medicine
  • Drug Stability
  • Anemia, Iron-Deficiency
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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Gupta, A., & Crumbliss, A. L. (2000). Treatment of iron deficiency anemia: are monomeric iron compounds suitable for parenteral administration? The Journal of Laboratory and Clinical Medicine, 136(5), 371–378. https://doi.org/10.1067/mlc.2000.110368
Gupta, A., and A. L. Crumbliss. “Treatment of iron deficiency anemia: are monomeric iron compounds suitable for parenteral administration?The Journal of Laboratory and Clinical Medicine 136, no. 5 (November 2000): 371–78. https://doi.org/10.1067/mlc.2000.110368.
Gupta A, Crumbliss AL. Treatment of iron deficiency anemia: are monomeric iron compounds suitable for parenteral administration? The Journal of laboratory and clinical medicine. 2000 Nov;136(5):371–8.
Gupta, A., and A. L. Crumbliss. “Treatment of iron deficiency anemia: are monomeric iron compounds suitable for parenteral administration?The Journal of Laboratory and Clinical Medicine, vol. 136, no. 5, Nov. 2000, pp. 371–78. Epmc, doi:10.1067/mlc.2000.110368.
Gupta A, Crumbliss AL. Treatment of iron deficiency anemia: are monomeric iron compounds suitable for parenteral administration? The Journal of laboratory and clinical medicine. 2000 Nov;136(5):371–378.

Published In

The Journal of laboratory and clinical medicine

DOI

EISSN

1532-6543

ISSN

0022-2143

Publication Date

November 2000

Volume

136

Issue

5

Start / End Page

371 / 378

Related Subject Headings

  • Iron
  • Injections
  • Humans
  • General Clinical Medicine
  • Drug Stability
  • Anemia, Iron-Deficiency
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
  • 1103 Clinical Sciences