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Synthesis of new classes of boron-containing nucleotides.

Publication ,  Journal Article
Lin, J; Shaw, BR
Published in: Nucleosides, nucleotides & nucleic acids
April 2001

Four different types of boron-modified nucleotides are reported: P-boranophosphorothioates, P-cyanoboranophosphates, P-boranomethylphosphonates, and P3'-N5'-boranophosphoramidates. Synthesis of dinucleoside borano-phosphorothioates and nucleoside P-borano-P-thiomonophosphates via a lithium sulfide method is described. The Li2S method also provides an alternative way to synthesize phosphorothioates through a dinitrophenyl P(V) phosphotriester precursor. The mechanism of Li2S substitution was investigated.

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Published In

Nucleosides, nucleotides & nucleic acids

DOI

EISSN

1532-2335

ISSN

1525-7770

Publication Date

April 2001

Volume

20

Issue

4-7

Start / End Page

587 / 596

Related Subject Headings

  • Thionucleotides
  • Organophosphonates
  • Organic Chemistry
  • Nucleotides
  • Magnetic Resonance Spectroscopy
  • Boron Compounds
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

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ICMJE
MLA
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Lin, J., & Shaw, B. R. (2001). Synthesis of new classes of boron-containing nucleotides. Nucleosides, Nucleotides & Nucleic Acids, 20(4–7), 587–596. https://doi.org/10.1081/ncn-100002335
Lin, J., and B. R. Shaw. “Synthesis of new classes of boron-containing nucleotides.Nucleosides, Nucleotides & Nucleic Acids 20, no. 4–7 (April 2001): 587–96. https://doi.org/10.1081/ncn-100002335.
Lin J, Shaw BR. Synthesis of new classes of boron-containing nucleotides. Nucleosides, nucleotides & nucleic acids. 2001 Apr;20(4–7):587–96.
Lin, J., and B. R. Shaw. “Synthesis of new classes of boron-containing nucleotides.Nucleosides, Nucleotides & Nucleic Acids, vol. 20, no. 4–7, Apr. 2001, pp. 587–96. Epmc, doi:10.1081/ncn-100002335.
Lin J, Shaw BR. Synthesis of new classes of boron-containing nucleotides. Nucleosides, nucleotides & nucleic acids. 2001 Apr;20(4–7):587–596.

Published In

Nucleosides, nucleotides & nucleic acids

DOI

EISSN

1532-2335

ISSN

1525-7770

Publication Date

April 2001

Volume

20

Issue

4-7

Start / End Page

587 / 596

Related Subject Headings

  • Thionucleotides
  • Organophosphonates
  • Organic Chemistry
  • Nucleotides
  • Magnetic Resonance Spectroscopy
  • Boron Compounds
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology