Synthesis of new classes of boron-containing nucleotides.
Publication
, Journal Article
Lin, J; Shaw, BR
Published in: Nucleosides, nucleotides & nucleic acids
April 2001
Four different types of boron-modified nucleotides are reported: P-boranophosphorothioates, P-cyanoboranophosphates, P-boranomethylphosphonates, and P3'-N5'-boranophosphoramidates. Synthesis of dinucleoside borano-phosphorothioates and nucleoside P-borano-P-thiomonophosphates via a lithium sulfide method is described. The Li2S method also provides an alternative way to synthesize phosphorothioates through a dinitrophenyl P(V) phosphotriester precursor. The mechanism of Li2S substitution was investigated.
Duke Scholars
Published In
Nucleosides, nucleotides & nucleic acids
DOI
EISSN
1532-2335
ISSN
1525-7770
Publication Date
April 2001
Volume
20
Issue
4-7
Start / End Page
587 / 596
Related Subject Headings
- Thionucleotides
- Organophosphonates
- Organic Chemistry
- Nucleotides
- Magnetic Resonance Spectroscopy
- Boron Compounds
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lin, J., & Shaw, B. R. (2001). Synthesis of new classes of boron-containing nucleotides. Nucleosides, Nucleotides & Nucleic Acids, 20(4–7), 587–596. https://doi.org/10.1081/ncn-100002335
Lin, J., and B. R. Shaw. “Synthesis of new classes of boron-containing nucleotides.” Nucleosides, Nucleotides & Nucleic Acids 20, no. 4–7 (April 2001): 587–96. https://doi.org/10.1081/ncn-100002335.
Lin J, Shaw BR. Synthesis of new classes of boron-containing nucleotides. Nucleosides, nucleotides & nucleic acids. 2001 Apr;20(4–7):587–96.
Lin, J., and B. R. Shaw. “Synthesis of new classes of boron-containing nucleotides.” Nucleosides, Nucleotides & Nucleic Acids, vol. 20, no. 4–7, Apr. 2001, pp. 587–96. Epmc, doi:10.1081/ncn-100002335.
Lin J, Shaw BR. Synthesis of new classes of boron-containing nucleotides. Nucleosides, nucleotides & nucleic acids. 2001 Apr;20(4–7):587–596.
Published In
Nucleosides, nucleotides & nucleic acids
DOI
EISSN
1532-2335
ISSN
1525-7770
Publication Date
April 2001
Volume
20
Issue
4-7
Start / End Page
587 / 596
Related Subject Headings
- Thionucleotides
- Organophosphonates
- Organic Chemistry
- Nucleotides
- Magnetic Resonance Spectroscopy
- Boron Compounds
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology