Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate.
Publication
, Journal Article
Lin, J; Shaw, BR
Published in: Nucleosides, nucleotides & nucleic acids
April 2001
A new type of non-ionic nucleotide analogue with a doubly modified internucleotide linkage, P-boranomethylphosphonate, has been successfully synthesized and characterized. Dithymidine boranomethylphosphonate 5 is the first example of a P-boranomethylphosphonate compound; it is a highly lipophilic phosphodiester analog, which is almost totally resistant to both snake venom phosphodiesterase (SVPDE) and bovine spleen phosphodiesterase (BSPDE). P-boranomethylphosphonates are expected to be promising candidates for mechanistic, diagnostic and therapeutic applications.
Duke Scholars
Published In
Nucleosides, nucleotides & nucleic acids
DOI
EISSN
1532-2335
ISSN
1525-7770
Publication Date
April 2001
Volume
20
Issue
4-7
Start / End Page
1325 / 1328
Related Subject Headings
- Organic Chemistry
- Nucleotides
- Nucleic Acids
- Molecular Mimicry
- Boranes
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lin, J., & Shaw, B. R. (2001). Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate. Nucleosides, Nucleotides & Nucleic Acids, 20(4–7), 1325–1328. https://doi.org/10.1081/ncn-100002547
Lin, J., and B. R. Shaw. “Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate.” Nucleosides, Nucleotides & Nucleic Acids 20, no. 4–7 (April 2001): 1325–28. https://doi.org/10.1081/ncn-100002547.
Lin J, Shaw BR. Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate. Nucleosides, nucleotides & nucleic acids. 2001 Apr;20(4–7):1325–8.
Lin, J., and B. R. Shaw. “Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate.” Nucleosides, Nucleotides & Nucleic Acids, vol. 20, no. 4–7, Apr. 2001, pp. 1325–28. Epmc, doi:10.1081/ncn-100002547.
Lin J, Shaw BR. Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate. Nucleosides, nucleotides & nucleic acids. 2001 Apr;20(4–7):1325–1328.
Published In
Nucleosides, nucleotides & nucleic acids
DOI
EISSN
1532-2335
ISSN
1525-7770
Publication Date
April 2001
Volume
20
Issue
4-7
Start / End Page
1325 / 1328
Related Subject Headings
- Organic Chemistry
- Nucleotides
- Nucleic Acids
- Molecular Mimicry
- Boranes
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology