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Hypolipidemic activity of boronated nucleosides and nucleotides in rodents.

Publication ,  Journal Article
Hall, IH; Burnham, BS; Rajendran, KG; Chen, SY; Sood, A; Spielvogel, BF; Shaw, BR
Published in: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
January 1993

Base-boronated nucleoside and phosphate-boronated nucleotides were potent hypolipidemic agents in rodents, lowering both serum cholesterol and triglyceride levels. Rat VLDL and LDL cholesterol levels were generally reduced and HDL cholesterol levels were significantly elevated after 14 days dosing at 8 mg/kg/day. Tissue cholesterol, triglyceride and phospholipid levels were reduced by selected derivatives. Increased fecal excretion of lipids did not appear to be a mechanism by which these derivatives lowered serum lipids in rodents. Rather, the agents suppressed appetite and reduced the activities of rate-limiting enzymes for de novo lipid synthesis, specifically cytoplasmic acetyl CoA synthetase, squalene synthetase, and phosphatidylate phosphohydrolase with IC50 values of approximately 10(-5) m.

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Published In

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

EISSN

1950-6007

ISSN

0753-3322

Publication Date

January 1993

Volume

47

Issue

2-3

Start / End Page

79 / 87

Related Subject Headings

  • Rodentia
  • Rats, Sprague-Dawley
  • Rats
  • Oncology & Carcinogenesis
  • Nucleotides
  • Nucleosides
  • Mice, Inbred Strains
  • Mice
  • Hypolipidemic Agents
  • Cholesterol, VLDL
 

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Hall, I. H., Burnham, B. S., Rajendran, K. G., Chen, S. Y., Sood, A., Spielvogel, B. F., & Shaw, B. R. (1993). Hypolipidemic activity of boronated nucleosides and nucleotides in rodents. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 47(2–3), 79–87. https://doi.org/10.1016/0753-3322(93)90295-v
Hall, I. H., B. S. Burnham, K. G. Rajendran, S. Y. Chen, A. Sood, B. F. Spielvogel, and B. R. Shaw. “Hypolipidemic activity of boronated nucleosides and nucleotides in rodents.Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 47, no. 2–3 (January 1993): 79–87. https://doi.org/10.1016/0753-3322(93)90295-v.
Hall IH, Burnham BS, Rajendran KG, Chen SY, Sood A, Spielvogel BF, et al. Hypolipidemic activity of boronated nucleosides and nucleotides in rodents. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 1993 Jan;47(2–3):79–87.
Hall, I. H., et al. “Hypolipidemic activity of boronated nucleosides and nucleotides in rodents.Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 47, no. 2–3, Jan. 1993, pp. 79–87. Epmc, doi:10.1016/0753-3322(93)90295-v.
Hall IH, Burnham BS, Rajendran KG, Chen SY, Sood A, Spielvogel BF, Shaw BR. Hypolipidemic activity of boronated nucleosides and nucleotides in rodents. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 1993 Jan;47(2–3):79–87.
Journal cover image

Published In

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

EISSN

1950-6007

ISSN

0753-3322

Publication Date

January 1993

Volume

47

Issue

2-3

Start / End Page

79 / 87

Related Subject Headings

  • Rodentia
  • Rats, Sprague-Dawley
  • Rats
  • Oncology & Carcinogenesis
  • Nucleotides
  • Nucleosides
  • Mice, Inbred Strains
  • Mice
  • Hypolipidemic Agents
  • Cholesterol, VLDL