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Structure and synthesis of physoperuvine: x-ray crystal and molecular structures of the n-benzoyl derivatives of (±)-3- and (+)-4-methylaminocycloheptanone

Publication ,  Journal Article
Mcphail, AT; Reginald Pinder, A
Published in: Tetrahedron
January 1, 1984

Single-crystal X-ray analyses have defined the structures and solid-state conformations of (±)-N-benzoyl-3-methylaminocycloheptanone [(±)-3]and (+)-N-benzoyl-4-methylaminocycloheptanone [(±)4]. Resolution of (±)-[4- methylaminocycloheptanone α 1-hydroxytropane]to yield the (+)-enantiomer. Identical in all respects with the free base from natural (+)-physoperuvine, was achieved via the di-p-toluoyl-(+)-tartrate salt. © 1984.

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Published In

Tetrahedron

DOI

ISSN

0040-4020

Publication Date

January 1, 1984

Volume

40

Issue

10

Start / End Page

1661 / 1666

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

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Mcphail, A. T., & Reginald Pinder, A. (1984). Structure and synthesis of physoperuvine: x-ray crystal and molecular structures of the n-benzoyl derivatives of (±)-3- and (+)-4-methylaminocycloheptanone. Tetrahedron, 40(10), 1661–1666. https://doi.org/10.1016/S0040-4020(01)91114-7
Mcphail, A. T., and A. Reginald Pinder. “Structure and synthesis of physoperuvine: x-ray crystal and molecular structures of the n-benzoyl derivatives of (±)-3- and (+)-4-methylaminocycloheptanone.” Tetrahedron 40, no. 10 (January 1, 1984): 1661–66. https://doi.org/10.1016/S0040-4020(01)91114-7.
Mcphail, A. T., and A. Reginald Pinder. “Structure and synthesis of physoperuvine: x-ray crystal and molecular structures of the n-benzoyl derivatives of (±)-3- and (+)-4-methylaminocycloheptanone.” Tetrahedron, vol. 40, no. 10, Jan. 1984, pp. 1661–66. Scopus, doi:10.1016/S0040-4020(01)91114-7.
Journal cover image

Published In

Tetrahedron

DOI

ISSN

0040-4020

Publication Date

January 1, 1984

Volume

40

Issue

10

Start / End Page

1661 / 1666

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry