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Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata).

Publication ,  Journal Article
Wall, ME; Wani, MC; Manikumar, G; Taylor, H; Hughes, TJ; Gaetano, K; Gerwick, HW; McPhail, AT; McPhail, DR
Published in: Journal of natural products
September 1989

Two new compounds, cymobarbatol and 4-isocymobarbatol, were isolated from the marine alga Cymopolia barbata. The complete structures and absolute stereochemistries of these compounds were elucidated by a variety of spectroscopic techniques and X-ray crystallography. Both compounds were found to be nontoxic over a broad concentration range to Salmonella typhimurium strains T-98 and T-100. Both compounds exhibited strong inhibition of the mutagenicity of 2-aminoanthracene and ethyl methanesulfonate toward, respectively, the T-98 strain plus a metabolic activator and T-100.

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Published In

Journal of natural products

DOI

EISSN

1520-6025

ISSN

0163-3864

Publication Date

September 1989

Volume

52

Issue

5

Start / End Page

1092 / 1099

Related Subject Headings

  • Salmonella typhimurium
  • Mutation
  • Molecular Structure
  • Models, Molecular
  • Medicinal & Biomolecular Chemistry
  • Chlorophyta
  • Benzopyrans
  • 4208 Traditional, complementary and integrative medicine
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

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Wall, M. E., Wani, M. C., Manikumar, G., Taylor, H., Hughes, T. J., Gaetano, K., … McPhail, D. R. (1989). Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata). Journal of Natural Products, 52(5), 1092–1099. https://doi.org/10.1021/np50065a028
Wall, M. E., M. C. Wani, G. Manikumar, H. Taylor, T. J. Hughes, K. Gaetano, H. W. Gerwick, A. T. McPhail, and D. R. McPhail. “Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata).Journal of Natural Products 52, no. 5 (September 1989): 1092–99. https://doi.org/10.1021/np50065a028.
Wall ME, Wani MC, Manikumar G, Taylor H, Hughes TJ, Gaetano K, et al. Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata). Journal of natural products. 1989 Sep;52(5):1092–9.
Wall, M. E., et al. “Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata).Journal of Natural Products, vol. 52, no. 5, Sept. 1989, pp. 1092–99. Epmc, doi:10.1021/np50065a028.
Wall ME, Wani MC, Manikumar G, Taylor H, Hughes TJ, Gaetano K, Gerwick HW, McPhail AT, McPhail DR. Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata). Journal of natural products. 1989 Sep;52(5):1092–1099.
Journal cover image

Published In

Journal of natural products

DOI

EISSN

1520-6025

ISSN

0163-3864

Publication Date

September 1989

Volume

52

Issue

5

Start / End Page

1092 / 1099

Related Subject Headings

  • Salmonella typhimurium
  • Mutation
  • Molecular Structure
  • Models, Molecular
  • Medicinal & Biomolecular Chemistry
  • Chlorophyta
  • Benzopyrans
  • 4208 Traditional, complementary and integrative medicine
  • 11 Medical and Health Sciences
  • 06 Biological Sciences