Total Synthesis of Griseolic Acid Derivatives from D-Glucose
Publication
, Journal Article
Tulshian, D; Doll, RJ; Stansberry, MF; McPhail, AT
Published in: Journal of Organic Chemistry
November 1, 1991
Griseolic acid, 1, is a potent nonselective cyclic nucleotide-phosphodiesterase inhibitor isolated from Streptomyces Griseoaurantiacus. Recently, preparation of several griseolic acid derivatives, including 3, has been reported. We have completed the chiral total synthesis of several griseolic acid derivatives. Here, we report on total syntheses of two cis-fused 4′,5′-dihydro-7′-deoxy griseolic acid derivatives, 4 and 5, from D-glucose. © 1991, American Chemical Society. All rights reserved.
Duke Scholars
Published In
Journal of Organic Chemistry
DOI
EISSN
1520-6904
ISSN
0022-3263
Publication Date
November 1, 1991
Volume
56
Issue
24
Start / End Page
6819 / 6822
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Tulshian, D., Doll, R. J., Stansberry, M. F., & McPhail, A. T. (1991). Total Synthesis of Griseolic Acid Derivatives from D-Glucose. Journal of Organic Chemistry, 56(24), 6819–6822. https://doi.org/10.1021/jo00024a022
Tulshian, D., R. J. Doll, M. F. Stansberry, and A. T. McPhail. “Total Synthesis of Griseolic Acid Derivatives from D-Glucose.” Journal of Organic Chemistry 56, no. 24 (November 1, 1991): 6819–22. https://doi.org/10.1021/jo00024a022.
Tulshian D, Doll RJ, Stansberry MF, McPhail AT. Total Synthesis of Griseolic Acid Derivatives from D-Glucose. Journal of Organic Chemistry. 1991 Nov 1;56(24):6819–22.
Tulshian, D., et al. “Total Synthesis of Griseolic Acid Derivatives from D-Glucose.” Journal of Organic Chemistry, vol. 56, no. 24, Nov. 1991, pp. 6819–22. Scopus, doi:10.1021/jo00024a022.
Tulshian D, Doll RJ, Stansberry MF, McPhail AT. Total Synthesis of Griseolic Acid Derivatives from D-Glucose. Journal of Organic Chemistry. 1991 Nov 1;56(24):6819–6822.
Published In
Journal of Organic Chemistry
DOI
EISSN
1520-6904
ISSN
0022-3263
Publication Date
November 1, 1991
Volume
56
Issue
24
Start / End Page
6819 / 6822
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry