Preparation and characterization of New C-11 oxygenated artemisinin derivatives
Publication
, Journal Article
Hufford, CD; Khalifa, SI; McPhail, AT; El-Feraly, FS; Ahmad, MS
Published in: Journal of Natural Products
January 1, 1993
Anhydrodihydroartemisinin [2], a potent antimalarial sesquiterpene endoperoxide, was converted to 11-hydroxyartemisinin [4], 11-hydroxy-11-epi-anemisinin [5], a ketone derivative 7 of artemisinin, and an enol ether epoxide 8. Compounds 4, 5, 7, and 8 were characterized completely by spectral methods including 1H-nmr and 13C-nmr spectroscopy. The stereochemistry of the epoxide 8 was established unequivocally by X-ray crystallographic analysis. © 1993, American Chemical Society. All rights reserved.
Duke Scholars
Published In
Journal of Natural Products
DOI
EISSN
1520-6025
ISSN
0163-3864
Publication Date
January 1, 1993
Volume
56
Issue
1
Start / End Page
62 / 66
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
- 06 Biological Sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Hufford, C. D., Khalifa, S. I., McPhail, A. T., El-Feraly, F. S., & Ahmad, M. S. (1993). Preparation and characterization of New C-11 oxygenated artemisinin derivatives. Journal of Natural Products, 56(1), 62–66. https://doi.org/10.1021/np50091a009
Hufford, C. D., S. I. Khalifa, A. T. McPhail, F. S. El-Feraly, and M. S. Ahmad. “Preparation and characterization of New C-11 oxygenated artemisinin derivatives.” Journal of Natural Products 56, no. 1 (January 1, 1993): 62–66. https://doi.org/10.1021/np50091a009.
Hufford CD, Khalifa SI, McPhail AT, El-Feraly FS, Ahmad MS. Preparation and characterization of New C-11 oxygenated artemisinin derivatives. Journal of Natural Products. 1993 Jan 1;56(1):62–6.
Hufford, C. D., et al. “Preparation and characterization of New C-11 oxygenated artemisinin derivatives.” Journal of Natural Products, vol. 56, no. 1, Jan. 1993, pp. 62–66. Scopus, doi:10.1021/np50091a009.
Hufford CD, Khalifa SI, McPhail AT, El-Feraly FS, Ahmad MS. Preparation and characterization of New C-11 oxygenated artemisinin derivatives. Journal of Natural Products. 1993 Jan 1;56(1):62–66.
Published In
Journal of Natural Products
DOI
EISSN
1520-6025
ISSN
0163-3864
Publication Date
January 1, 1993
Volume
56
Issue
1
Start / End Page
62 / 66
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
- 06 Biological Sciences
- 03 Chemical Sciences