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NHERF: targeting and trafficking membrane proteins.

Publication ,  Journal Article
Shenolikar, S; Weinman, EJ
Published in: Am J Physiol Renal Physiol
March 2001

Vectorial ion transport initiated by Na+/H+ exchanger isoform 3 (NHE3) mediates the reabsorption of NaCl and NaHCO(3) in renal proximal tubule cells. NHE3 activity is modulated by numerous physiological stimuli. Biochemical and cellular experiments identified Na+/H+ exchanger regulatory factor (NHERF) as a protein cofactor essential for cAMP-mediated inhibition of NHE3 activity. Identification of numerous NHERF targets, including several transmembrane receptors and ion transporters, has broadened the role of this PSD-95/Dlg-1, Drososphila disk large/ZO-1 domain-containing adapter protein in membrane physiology. NHERF also associates with members of the ezrin/radixin/moesin family of actin-binding proteins and thus links NHE3 to the actin cytoskeleton. Formation of this multiprotein complex facilitates NHE3 phosphorylation and hormonal control of Na+/H+ exchange. NHERF also plays a critical role in targeting transport proteins to apical membranes. Moreover, the NHERF signaling complex functions as a regulatory unit to control endocytosis and internal trafficking of membrane proteins. This article reviews the new evidence that implicates NHERF in wider aspects of epithelial membrane biology.

Duke Scholars

Published In

Am J Physiol Renal Physiol

DOI

ISSN

1931-857X

Publication Date

March 2001

Volume

280

Issue

3

Start / End Page

F389 / F395

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Sodium-Hydrogen Exchangers
  • Sodium-Hydrogen Exchanger 3
  • Phosphorylation
  • Phosphoproteins
  • Membrane Proteins
  • Endocytosis
  • Cytoskeleton
  • Cytoskeletal Proteins
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shenolikar, S., & Weinman, E. J. (2001). NHERF: targeting and trafficking membrane proteins. Am J Physiol Renal Physiol, 280(3), F389–F395. https://doi.org/10.1152/ajprenal.2001.280.3.F389
Shenolikar, S., and E. J. Weinman. “NHERF: targeting and trafficking membrane proteins.Am J Physiol Renal Physiol 280, no. 3 (March 2001): F389–95. https://doi.org/10.1152/ajprenal.2001.280.3.F389.
Shenolikar S, Weinman EJ. NHERF: targeting and trafficking membrane proteins. Am J Physiol Renal Physiol. 2001 Mar;280(3):F389–95.
Shenolikar, S., and E. J. Weinman. “NHERF: targeting and trafficking membrane proteins.Am J Physiol Renal Physiol, vol. 280, no. 3, Mar. 2001, pp. F389–95. Pubmed, doi:10.1152/ajprenal.2001.280.3.F389.
Shenolikar S, Weinman EJ. NHERF: targeting and trafficking membrane proteins. Am J Physiol Renal Physiol. 2001 Mar;280(3):F389–F395.

Published In

Am J Physiol Renal Physiol

DOI

ISSN

1931-857X

Publication Date

March 2001

Volume

280

Issue

3

Start / End Page

F389 / F395

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Sodium-Hydrogen Exchangers
  • Sodium-Hydrogen Exchanger 3
  • Phosphorylation
  • Phosphoproteins
  • Membrane Proteins
  • Endocytosis
  • Cytoskeleton
  • Cytoskeletal Proteins
  • Animals