Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.
Publication
, Journal Article
Ichinose, M; Endo, S; Critz, SD; Shenolikar, S; Byrne, JH
Published in: Brain Res
November 12, 1990
Microcystin-LR (MCYST-LR), a hepatotoxin produced by cyanobacteria, inhibited purified protein phosphatases (PrPs) from rabbit skeletal muscle and the enzymes from Aplysia with an IC50 of approximately 10(-10) M. MCYST-LR also prolonged both serotonin- (5-HT) and cyclic adenosine monophosphate-induced inward currents in sensory neurons of Aplysia. These results, which are consistent with inhibition of Aplysia PrPs, indicate that MCYST-LR may be a useful probe to elucidate the function of PrPs in neural tissues.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
November 12, 1990
Volume
533
Issue
1
Start / End Page
137 / 140
Location
Netherlands
Related Subject Headings
- Serotonin
- Phosphoprotein Phosphatases
- Peptides, Cyclic
- Neurons, Afferent
- Neurology & Neurosurgery
- Microcystins
- Membrane Potentials
- Marine Toxins
- Dose-Response Relationship, Drug
- Cyclic AMP
Citation
APA
Chicago
ICMJE
MLA
NLM
Ichinose, M., Endo, S., Critz, S. D., Shenolikar, S., & Byrne, J. H. (1990). Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica. Brain Res, 533(1), 137–140. https://doi.org/10.1016/0006-8993(90)91806-r
Ichinose, M., S. Endo, S. D. Critz, S. Shenolikar, and J. H. Byrne. “Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.” Brain Res 533, no. 1 (November 12, 1990): 137–40. https://doi.org/10.1016/0006-8993(90)91806-r.
Ichinose M, Endo S, Critz SD, Shenolikar S, Byrne JH. Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica. Brain Res. 1990 Nov 12;533(1):137–40.
Ichinose, M., et al. “Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.” Brain Res, vol. 533, no. 1, Nov. 1990, pp. 137–40. Pubmed, doi:10.1016/0006-8993(90)91806-r.
Ichinose M, Endo S, Critz SD, Shenolikar S, Byrne JH. Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica. Brain Res. 1990 Nov 12;533(1):137–140.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
November 12, 1990
Volume
533
Issue
1
Start / End Page
137 / 140
Location
Netherlands
Related Subject Headings
- Serotonin
- Phosphoprotein Phosphatases
- Peptides, Cyclic
- Neurons, Afferent
- Neurology & Neurosurgery
- Microcystins
- Membrane Potentials
- Marine Toxins
- Dose-Response Relationship, Drug
- Cyclic AMP