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Regulation of synaptic strength by protein phosphatase 1.

Publication ,  Journal Article
Morishita, W; Connor, JH; Xia, H; Quinlan, EM; Shenolikar, S; Malenka, RC
Published in: Neuron
December 20, 2001

We investigated the role of postsynaptic protein phosphatase 1 (PP1) in regulating synaptic strength by loading CA1 pyramidal cells either with peptides that disrupt PP1 binding to synaptic targeting proteins or with active PP1. The peptides blocked synaptically evoked LTD but had no effect on basal synaptic currents mediated by either AMPA or NMDA receptors. They did, however, cause an increase in synaptic strength following the induction of LTD. Similarly, PP1 had no effect on basal synaptic strength but enhanced LTD. In cultured neurons, synaptic activation of NMDA receptors increased the proportion of PP1 localized to synapses. These results suggest that PP1 does not significantly regulate basal synaptic strength. Appropriate NMDA receptor activation, however, allows PP1 to gain access to synaptic substrates and be recruited to synapses where its activity is necessary for sustaining LTD.

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Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

December 20, 2001

Volume

32

Issue

6

Start / End Page

1133 / 1148

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Metabotropic Glutamate
  • Receptors, AMPA
  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Cells
  • Protein Phosphatase 1
  • Phosphoprotein Phosphatases
 

Citation

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Morishita, W., Connor, J. H., Xia, H., Quinlan, E. M., Shenolikar, S., & Malenka, R. C. (2001). Regulation of synaptic strength by protein phosphatase 1. Neuron, 32(6), 1133–1148. https://doi.org/10.1016/s0896-6273(01)00554-2
Morishita, W., J. H. Connor, H. Xia, E. M. Quinlan, S. Shenolikar, and R. C. Malenka. “Regulation of synaptic strength by protein phosphatase 1.Neuron 32, no. 6 (December 20, 2001): 1133–48. https://doi.org/10.1016/s0896-6273(01)00554-2.
Morishita W, Connor JH, Xia H, Quinlan EM, Shenolikar S, Malenka RC. Regulation of synaptic strength by protein phosphatase 1. Neuron. 2001 Dec 20;32(6):1133–48.
Morishita, W., et al. “Regulation of synaptic strength by protein phosphatase 1.Neuron, vol. 32, no. 6, Dec. 2001, pp. 1133–48. Pubmed, doi:10.1016/s0896-6273(01)00554-2.
Morishita W, Connor JH, Xia H, Quinlan EM, Shenolikar S, Malenka RC. Regulation of synaptic strength by protein phosphatase 1. Neuron. 2001 Dec 20;32(6):1133–1148.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

December 20, 2001

Volume

32

Issue

6

Start / End Page

1133 / 1148

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Metabotropic Glutamate
  • Receptors, AMPA
  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Cells
  • Protein Phosphatase 1
  • Phosphoprotein Phosphatases