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A relationship between behavior, neurotrophin expression, and new neuron survival.

Publication ,  Journal Article
Li, XC; Jarvis, ED; Alvarez-Borda, B; Lim, DA; Nottebohm, F
Published in: Proc Natl Acad Sci U S A
July 18, 2000

The high vocal center (HVC) controls song production in songbirds and sends a projection to the robust nucleus of the archistriatum (RA) of the descending vocal pathway. HVC receives new neurons in adulthood. Most of the new neurons project to RA and replace other neurons of the same kind. We show here that singing enhances mRNA and protein expression of brain-derived neurotrophic factor (BDNF) in the HVC of adult male canaries, Serinus canaria. The increased BDNF expression is proportional to the number of songs produced per unit time. Singing-induced BDNF expression in HVC occurs mainly in the RA-projecting neurons. Neuronal survival was compared among birds that did or did not sing during days 31-38 after BrdUrd injection. Survival of new HVC neurons is greater in the singing birds than in the nonsinging birds. A positive causal link between pathway use, neurotrophin expression, and new neuron survival may be common among systems that recruit new neurons in adulthood.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

July 18, 2000

Volume

97

Issue

15

Start / End Page

8584 / 8589

Location

United States

Related Subject Headings

  • Vocalization, Animal
  • RNA, Messenger
  • Neurons
  • Male
  • Humans
  • Gene Expression
  • Cell Survival
  • Canaries
  • Brain-Derived Neurotrophic Factor
  • Brain
 

Citation

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Li, X. C., Jarvis, E. D., Alvarez-Borda, B., Lim, D. A., & Nottebohm, F. (2000). A relationship between behavior, neurotrophin expression, and new neuron survival. Proc Natl Acad Sci U S A, 97(15), 8584–8589. https://doi.org/10.1073/pnas.140222497
Li, X. C., E. D. Jarvis, B. Alvarez-Borda, D. A. Lim, and F. Nottebohm. “A relationship between behavior, neurotrophin expression, and new neuron survival.Proc Natl Acad Sci U S A 97, no. 15 (July 18, 2000): 8584–89. https://doi.org/10.1073/pnas.140222497.
Li XC, Jarvis ED, Alvarez-Borda B, Lim DA, Nottebohm F. A relationship between behavior, neurotrophin expression, and new neuron survival. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8584–9.
Li, X. C., et al. “A relationship between behavior, neurotrophin expression, and new neuron survival.Proc Natl Acad Sci U S A, vol. 97, no. 15, July 2000, pp. 8584–89. Pubmed, doi:10.1073/pnas.140222497.
Li XC, Jarvis ED, Alvarez-Borda B, Lim DA, Nottebohm F. A relationship between behavior, neurotrophin expression, and new neuron survival. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8584–8589.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

July 18, 2000

Volume

97

Issue

15

Start / End Page

8584 / 8589

Location

United States

Related Subject Headings

  • Vocalization, Animal
  • RNA, Messenger
  • Neurons
  • Male
  • Humans
  • Gene Expression
  • Cell Survival
  • Canaries
  • Brain-Derived Neurotrophic Factor
  • Brain