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A review of the therapeutic uses of thrombin.

Publication ,  Journal Article
Lundblad, RL; Bradshaw, RA; Gabriel, D; Ortel, TL; Lawson, J; Mann, KG
Published in: Thromb Haemost
May 2004

Thrombin is the product of the hemostatic response essential to the conversion of fibrinogen to fibrin. In addition, it is also responsible for the aggregation of blood platelets in the formation of the "platelet plug" as well as the activation of factor VIII, factor V, factor XI, factor XIII and protein C. The action of thrombin is not confined to the hemostatic response as it also has a critical function in the wound healing process by stimulating 'mitogenic' events through interaction with cell surface receptors. In this review, we consider the various biological activities of thrombin as they relate to current therapeutic use. While there has been considerable interest in the development of fibrin sealant products, there has been considerably less interest in documenting the continuing use of thrombin as a therapeutic. The use of thrombin for topical hemostasis and the treatment of pseudoaneurysms will be discussed in detail. It is concluded that the use of thrombin as a drug will not only continue but also will significantly increase. However, the availability of a safe human thrombin preparation will be critical for the continued use of thrombin as a therapeutic.

Duke Scholars

Published In

Thromb Haemost

DOI

ISSN

0340-6245

Publication Date

May 2004

Volume

91

Issue

5

Start / End Page

851 / 860

Location

Germany

Related Subject Headings

  • Wound Healing
  • Thrombin
  • Humans
  • Hemostatic Techniques
  • Hemostasis
  • Cardiovascular System & Hematology
  • Aneurysm, False
  • Administration, Topical
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Chicago
ICMJE
MLA
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Lundblad, R. L., Bradshaw, R. A., Gabriel, D., Ortel, T. L., Lawson, J., & Mann, K. G. (2004). A review of the therapeutic uses of thrombin. Thromb Haemost, 91(5), 851–860. https://doi.org/10.1160/TH03-12-0792
Lundblad, Roger L., Ralph A. Bradshaw, Don Gabriel, Thomas L. Ortel, Jeffrey Lawson, and Kenneth G. Mann. “A review of the therapeutic uses of thrombin.Thromb Haemost 91, no. 5 (May 2004): 851–60. https://doi.org/10.1160/TH03-12-0792.
Lundblad RL, Bradshaw RA, Gabriel D, Ortel TL, Lawson J, Mann KG. A review of the therapeutic uses of thrombin. Thromb Haemost. 2004 May;91(5):851–60.
Lundblad, Roger L., et al. “A review of the therapeutic uses of thrombin.Thromb Haemost, vol. 91, no. 5, May 2004, pp. 851–60. Pubmed, doi:10.1160/TH03-12-0792.
Lundblad RL, Bradshaw RA, Gabriel D, Ortel TL, Lawson J, Mann KG. A review of the therapeutic uses of thrombin. Thromb Haemost. 2004 May;91(5):851–860.
Journal cover image

Published In

Thromb Haemost

DOI

ISSN

0340-6245

Publication Date

May 2004

Volume

91

Issue

5

Start / End Page

851 / 860

Location

Germany

Related Subject Headings

  • Wound Healing
  • Thrombin
  • Humans
  • Hemostatic Techniques
  • Hemostasis
  • Cardiovascular System & Hematology
  • Aneurysm, False
  • Administration, Topical
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology