A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.
Publication
, Journal Article
Tao, X; West, AE; Chen, WG; Corfas, G; Greenberg, ME
Published in: Neuron
January 31, 2002
Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium- and neuron-selective manner; however, the mechanisms that underlie this selectivity are not known. We have characterized a new calcium-response element, CaRE1, that is required for activity-dependent transcription of BDNF exon III and have cloned a transcription factor, CaRF, that activates transcription from BDNF promoter III in a CaRE1-dependent manner. The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Neuron
DOI
ISSN
0896-6273
Publication Date
January 31, 2002
Volume
33
Issue
3
Start / End Page
383 / 395
Location
United States
Related Subject Headings
- Two-Hybrid System Techniques
- Transcription Factors
- Tissue Distribution
- Response Elements
- Regulatory Sequences, Nucleic Acid
- Rats, Long-Evans
- Rats
- Phosphodiesterase Inhibitors
- Nuclear Proteins
- Neurons
Citation
APA
Chicago
ICMJE
MLA
NLM
Tao, X., West, A. E., Chen, W. G., Corfas, G., & Greenberg, M. E. (2002). A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron, 33(3), 383–395. https://doi.org/10.1016/s0896-6273(01)00561-x
Tao, Xu, Anne E. West, Wen G. Chen, Gabriel Corfas, and Michael E. Greenberg. “A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.” Neuron 33, no. 3 (January 31, 2002): 383–95. https://doi.org/10.1016/s0896-6273(01)00561-x.
Tao X, West AE, Chen WG, Corfas G, Greenberg ME. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31;33(3):383–95.
Tao, Xu, et al. “A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.” Neuron, vol. 33, no. 3, Jan. 2002, pp. 383–95. Pubmed, doi:10.1016/s0896-6273(01)00561-x.
Tao X, West AE, Chen WG, Corfas G, Greenberg ME. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31;33(3):383–395.
Published In
Neuron
DOI
ISSN
0896-6273
Publication Date
January 31, 2002
Volume
33
Issue
3
Start / End Page
383 / 395
Location
United States
Related Subject Headings
- Two-Hybrid System Techniques
- Transcription Factors
- Tissue Distribution
- Response Elements
- Regulatory Sequences, Nucleic Acid
- Rats, Long-Evans
- Rats
- Phosphodiesterase Inhibitors
- Nuclear Proteins
- Neurons