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Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats.

Publication ,  Journal Article
Levin, ED; Christopher, NC; Weaver, T; Moore, J; Brucato, F
Published in: Brain Res Cogn Brain Res
January 1999

Chronic nicotine infusions have been found to significantly improve working memory performance in the radial-arm maze. This effect is blocked by co-infusions of the nicotinic antagonist mecamylamine. Acute nicotine injections also improve working memory performance in the radial-arm maze. This effect is also blocked by mecamylamine co-administration. Recent local infusions studies have demonstrated the importance of the ventral hippocampus for nicotinic involvement in memory. Local infusions of mecamylamine, DHbetaE or MLA impair working memory performance on the radial-arm maze. The current study was conducted to determine the importance of the ventral hippocampus for the chronic effects of nicotine. Rats were trained on the working memory task in an eight-arm radial maze. After acquisition they underwent either infusions of ibotenic acid lesions or vehicle infusions and received subcutaneous implants of osmotic minipumps that delivered either nicotine at a dose of 5 mg kg-1 day-1 or vehicle in a 2x2 design. The rats then were given 2 days of recovery and were tested on the radial-arm maze three times per week for the next 4 weeks. As seen in previous studies, in the sham lesioned group nicotine infusions caused a significant improvement in choice accuracy. In contrast no nicotine-induced improvement was seen in the rats after ibotenic acid lesions of the ventral hippocampus. The effect of nicotine was blocked even though this lesion did not cause a deficit in performance. Previous work showed that chronic nicotine infusion still caused a significant improvement in working memory performance in the radial-arm maze after knife-cut lesions of the fimbria-fornix carrying the septo-hippocampal cholinergic innervation. Thus it appears that it is the postsynaptic nicotinic receptors in the ventral hippocampus which are critically important for the expression of the chronic nicotine induced working memory improvement.

Duke Scholars

Published In

Brain Res Cogn Brain Res

DOI

ISSN

0926-6410

Publication Date

January 1999

Volume

7

Issue

3

Start / End Page

405 / 410

Location

Netherlands

Related Subject Headings

  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
  • Nicotinic Agonists
  • Nicotine
  • Memory, Short-Term
  • Maze Learning
  • Ibotenic Acid
  • Hippocampus
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Levin, E. D., Christopher, N. C., Weaver, T., Moore, J., & Brucato, F. (1999). Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. Brain Res Cogn Brain Res, 7(3), 405–410. https://doi.org/10.1016/s0926-6410(98)00044-5
Levin, E. D., N. C. Christopher, T. Weaver, J. Moore, and F. Brucato. “Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats.Brain Res Cogn Brain Res 7, no. 3 (January 1999): 405–10. https://doi.org/10.1016/s0926-6410(98)00044-5.
Levin ED, Christopher NC, Weaver T, Moore J, Brucato F. Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. Brain Res Cogn Brain Res. 1999 Jan;7(3):405–10.
Levin, E. D., et al. “Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats.Brain Res Cogn Brain Res, vol. 7, no. 3, Jan. 1999, pp. 405–10. Pubmed, doi:10.1016/s0926-6410(98)00044-5.
Levin ED, Christopher NC, Weaver T, Moore J, Brucato F. Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats. Brain Res Cogn Brain Res. 1999 Jan;7(3):405–410.
Journal cover image

Published In

Brain Res Cogn Brain Res

DOI

ISSN

0926-6410

Publication Date

January 1999

Volume

7

Issue

3

Start / End Page

405 / 410

Location

Netherlands

Related Subject Headings

  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
  • Nicotinic Agonists
  • Nicotine
  • Memory, Short-Term
  • Maze Learning
  • Ibotenic Acid
  • Hippocampus
  • Female