Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel
Journal cover image

Memory decline of aging reduced by extracellular superoxide dismutase overexpression.

Publication ,  Journal Article
Levin, ED; Christopher, NC; Crapo, JD
Published in: Behav Genet
July 2005

Extracellular superoxide dismutase (EC-SOD) plays an important role in controlling oxidative stress as well as intercellular signaling. In the current study, we tested the effect of EC-SOD overexpression over the lifespan of a set of mice and their wild-type controls to determine the time scale over which EC-SOD overexpression might attenuate aging-induced memory impairment. Mice with overexpression of EC-SOD and wild-type controls were initially trained on the radial-arm maze as young adults (3-5 months) and then retrained during middle age (12-14 months) and retested in old age at 27 and 30 months. There was little EC-SOD effect during the young adult middle age periods. EC-SOD overexpression prevented the decline in choice accuracy when the mice were 27-30 months of age. The EC-SOD overexpressing mice maintained their performance, while the wild-type mice declined to naïve levels of performance by 30 months of age. Enhancement of EC-SOD activity appears to improve memory performance specifically in aging mice. EC-SOD mimetic treatment during the course of aging may hold promise for aging-induced cognitive impairment.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Behav Genet

DOI

ISSN

0001-8244

Publication Date

July 2005

Volume

35

Issue

4

Start / End Page

447 / 453

Location

United States

Related Subject Headings

  • Superoxide Dismutase
  • Signal Transduction
  • Oxidative Stress
  • Mice, Transgenic
  • Mice
  • Memory Disorders
  • Maze Learning
  • Genotype
  • Genetics & Heredity
  • Gene Expression Profiling
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levin, E. D., Christopher, N. C., & Crapo, J. D. (2005). Memory decline of aging reduced by extracellular superoxide dismutase overexpression. Behav Genet, 35(4), 447–453. https://doi.org/10.1007/s10519-004-1510-y
Levin, Edward D., N Channelle Christopher, and James D. Crapo. “Memory decline of aging reduced by extracellular superoxide dismutase overexpression.Behav Genet 35, no. 4 (July 2005): 447–53. https://doi.org/10.1007/s10519-004-1510-y.
Levin ED, Christopher NC, Crapo JD. Memory decline of aging reduced by extracellular superoxide dismutase overexpression. Behav Genet. 2005 Jul;35(4):447–53.
Levin, Edward D., et al. “Memory decline of aging reduced by extracellular superoxide dismutase overexpression.Behav Genet, vol. 35, no. 4, July 2005, pp. 447–53. Pubmed, doi:10.1007/s10519-004-1510-y.
Levin ED, Christopher NC, Crapo JD. Memory decline of aging reduced by extracellular superoxide dismutase overexpression. Behav Genet. 2005 Jul;35(4):447–453.
Journal cover image

Published In

Behav Genet

DOI

ISSN

0001-8244

Publication Date

July 2005

Volume

35

Issue

4

Start / End Page

447 / 453

Location

United States

Related Subject Headings

  • Superoxide Dismutase
  • Signal Transduction
  • Oxidative Stress
  • Mice, Transgenic
  • Mice
  • Memory Disorders
  • Maze Learning
  • Genotype
  • Genetics & Heredity
  • Gene Expression Profiling