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Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.

Publication ,  Journal Article
Finger, LR; Kagan, J; Christopher, G; Kurtzberg, J; Hershfield, MS; Nowell, PC; Croce, CM
Published in: Proc Natl Acad Sci U S A
July 1989

We analyzed a t(1;14)(p32;q11) chromosomal translocation in a human lymphohemopoietic stem cell line derived from a patient with acute T-lymphoblastic leukemia. The chromosomal joining on the 1p+ chromosome occurred at the T-cell receptor delta diversity (D delta 2) segment, and the reciprocal chromosomal joining on the 14q- chromosome occurred at the T-cell delta diversity segment D delta 1. The involvement of delta diversity segments at the translocation junctions suggests that the translocation occurred during an attempt at D delta 1-D delta 2 joining in a stem cell. The segment of chromosome 1 at band p32, adjacent to the chromosomal breakpoint, encodes a transcriptional unit designated TCL5 (T-cell leukemia/lymphoma 5). The differential expression of the TCL5 RNA transcripts in this lymphohemopoietic stem cell line relative to several other T- and B-cell lines suggests that TCL5 gene expression is an integral event in the pathogenesis of the T-cell leukemia. Rearrangement of the TCL5 locus in a human melanoma cell line carrying a del(1p32) further implies that the TCL5 gene may play a role in malignant transformation.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

July 1989

Volume

86

Issue

13

Start / End Page

5039 / 5043

Location

United States

Related Subject Headings

  • Translocation, Genetic
  • Restriction Mapping
  • Receptors, Antigen, T-Cell
  • Nucleic Acid Hybridization
  • Molecular Sequence Data
  • Melanoma
  • Leukemia, T-Cell
  • Humans
  • Genes, Immunoglobulin
  • Gene Rearrangement, T-Lymphocyte
 

Citation

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MLA
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Finger, L. R., Kagan, J., Christopher, G., Kurtzberg, J., Hershfield, M. S., Nowell, P. C., & Croce, C. M. (1989). Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A, 86(13), 5039–5043. https://doi.org/10.1073/pnas.86.13.5039
Finger, L. R., J. Kagan, G. Christopher, J. Kurtzberg, M. S. Hershfield, P. C. Nowell, and C. M. Croce. “Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.Proc Natl Acad Sci U S A 86, no. 13 (July 1989): 5039–43. https://doi.org/10.1073/pnas.86.13.5039.
Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, et al. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5039–43.
Finger, L. R., et al. “Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.Proc Natl Acad Sci U S A, vol. 86, no. 13, July 1989, pp. 5039–43. Pubmed, doi:10.1073/pnas.86.13.5039.
Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5039–5043.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

July 1989

Volume

86

Issue

13

Start / End Page

5039 / 5043

Location

United States

Related Subject Headings

  • Translocation, Genetic
  • Restriction Mapping
  • Receptors, Antigen, T-Cell
  • Nucleic Acid Hybridization
  • Molecular Sequence Data
  • Melanoma
  • Leukemia, T-Cell
  • Humans
  • Genes, Immunoglobulin
  • Gene Rearrangement, T-Lymphocyte