Post-prenylation-processing enzymes as new targets in oncogenesis.
RAS and many other oncogenic proteins undergo a complex series of post-translational modifications that are initiated by the addition of an isoprenoid lipid through a process known as prenylation. Following prenylation, these proteins usually undergo endoproteolytic processing by the RCE1 protease and then carboxyl methylation by a unique methyltransferase known as isoprenylcysteine carboxyl methyltransferase (ICMT). Although inhibitors that have been designed to target the prenylation step are now in advanced-stage clinical trials, their utility and efficacy seem to be limited. Recent findings, however, indicate that the inhibition of these post-prenylation-processing steps--particularly that of ICMT-catalysed methylation--might provide a better approach to the control of cancer-cell proliferation.
Duke Scholars
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- ras Proteins
- Protein Processing, Post-Translational
- Protein Prenylation
- Protein Methyltransferases
- Oncology & Carcinogenesis
- Neoplasms
- Humans
- Endopeptidases
- Cell Proliferation
- Animals
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- ras Proteins
- Protein Processing, Post-Translational
- Protein Prenylation
- Protein Methyltransferases
- Oncology & Carcinogenesis
- Neoplasms
- Humans
- Endopeptidases
- Cell Proliferation
- Animals