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Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.

Publication ,  Journal Article
Mijimolle, N; Velasco, J; Dubus, P; Guerra, C; Weinbaum, CA; Casey, PJ; Campuzano, V; Barbacid, M
Published in: Cancer Cell
April 2005

Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development.

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Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

April 2005

Volume

7

Issue

4

Start / End Page

313 / 324

Location

United States

Related Subject Headings

  • ras Proteins
  • Wound Healing
  • Tamoxifen
  • Spleen
  • Skin Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutation
  • Mice, Knockout
  • Mice
 

Citation

APA
Chicago
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MLA
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Mijimolle, N., Velasco, J., Dubus, P., Guerra, C., Weinbaum, C. A., Casey, P. J., … Barbacid, M. (2005). Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell, 7(4), 313–324. https://doi.org/10.1016/j.ccr.2005.03.004
Mijimolle, Nieves, Juan Velasco, Pierre Dubus, Carmen Guerra, Carolyn A. Weinbaum, Patrick J. Casey, Victoria Campuzano, and Mariano Barbacid. “Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.Cancer Cell 7, no. 4 (April 2005): 313–24. https://doi.org/10.1016/j.ccr.2005.03.004.
Mijimolle N, Velasco J, Dubus P, Guerra C, Weinbaum CA, Casey PJ, et al. Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell. 2005 Apr;7(4):313–24.
Mijimolle, Nieves, et al. “Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.Cancer Cell, vol. 7, no. 4, Apr. 2005, pp. 313–24. Pubmed, doi:10.1016/j.ccr.2005.03.004.
Mijimolle N, Velasco J, Dubus P, Guerra C, Weinbaum CA, Casey PJ, Campuzano V, Barbacid M. Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell. 2005 Apr;7(4):313–324.
Journal cover image

Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

April 2005

Volume

7

Issue

4

Start / End Page

313 / 324

Location

United States

Related Subject Headings

  • ras Proteins
  • Wound Healing
  • Tamoxifen
  • Spleen
  • Skin Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasms
  • Mutation
  • Mice, Knockout
  • Mice