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MR imaging contrast enhancement based on intermolecular zero quantum coherences.

Publication ,  Journal Article
Warren, WS; Ahn, S; Mescher, M; Garwood, M; Ugurbil, K; Richter, W; Rizi, RR; Hopkins, J; Leigh, JS
Published in: Science (New York, N.Y.)
July 1998

A new method for magnetic resonance imaging (MRI) based on the detection of relatively strong signal from intermolecular zero-quantum coherences (iZQCs) is reported. Such a signal would not be observable in the conventional framework of magnetic resonance; it originates in long-range dipolar couplings (10 micrometers to 1 millimeter) that are traditionally ignored. Unlike conventional MRI, where image contrast is based on variations in spin density and relaxation times (often with injected contrast agents), contrast with iZQC images comes from variations in the susceptibility over a distance dictated by gradient strength. Phantom and in vivo (rat brain) data confirm that iZQC images give contrast enhancement. This contrast might be useful in the detection of small tumors, in that susceptibility correlates with oxygen concentration and in functional MRI.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 1998

Volume

281

Issue

5374

Start / End Page

247 / 251

Related Subject Headings

  • Rats
  • Phantoms, Imaging
  • Mathematics
  • Magnetics
  • Magnetic Resonance Imaging
  • General Science & Technology
  • Brain Neoplasms
  • Brain Mapping
  • Brain
  • Animals
 

Citation

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Warren, W. S., Ahn, S., Mescher, M., Garwood, M., Ugurbil, K., Richter, W., … Leigh, J. S. (1998). MR imaging contrast enhancement based on intermolecular zero quantum coherences. Science (New York, N.Y.), 281(5374), 247–251. https://doi.org/10.1126/science.281.5374.247
Warren, W. S., S. Ahn, M. Mescher, M. Garwood, K. Ugurbil, W. Richter, R. R. Rizi, J. Hopkins, and J. S. Leigh. “MR imaging contrast enhancement based on intermolecular zero quantum coherences.Science (New York, N.Y.) 281, no. 5374 (July 1998): 247–51. https://doi.org/10.1126/science.281.5374.247.
Warren WS, Ahn S, Mescher M, Garwood M, Ugurbil K, Richter W, et al. MR imaging contrast enhancement based on intermolecular zero quantum coherences. Science (New York, NY). 1998 Jul;281(5374):247–51.
Warren, W. S., et al. “MR imaging contrast enhancement based on intermolecular zero quantum coherences.Science (New York, N.Y.), vol. 281, no. 5374, July 1998, pp. 247–51. Epmc, doi:10.1126/science.281.5374.247.
Warren WS, Ahn S, Mescher M, Garwood M, Ugurbil K, Richter W, Rizi RR, Hopkins J, Leigh JS. MR imaging contrast enhancement based on intermolecular zero quantum coherences. Science (New York, NY). 1998 Jul;281(5374):247–251.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 1998

Volume

281

Issue

5374

Start / End Page

247 / 251

Related Subject Headings

  • Rats
  • Phantoms, Imaging
  • Mathematics
  • Magnetics
  • Magnetic Resonance Imaging
  • General Science & Technology
  • Brain Neoplasms
  • Brain Mapping
  • Brain
  • Animals