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Intravascular malignant lymphomatosis with neurologic presentation: factors facilitating antemortem diagnosis.

Publication ,  Journal Article
Devlin, T; Moll, S; Hulette, C; Morgenlander, JC
Published in: South Med J
July 1998

Intravascular malignant lymphomatosis (IML) is a rare disorder of small and medium size vessels that frequently goes undiagnosed until the time of autopsy. The clinical courses of two such patients were examined to determine factors that would facilitate antemortem diagnosis. Both patients had mental status changes, pyramidal tract signs, and peripheral neuropathy. Despite postmortem evidence of widespread lymphocytic invasion of vessels throughout the body including peripheral and central nervous systems, neuroimaging studies, cerebrospinal fluid analysis, peripheral blood studies, and bone marrow biopsy failed to reveal diagnostic evidence of the underlying neoplastic process. Although markedly abnormal, nerve conduction studies were nonspecific. Familiarity with IML and its consideration in the differential diagnosis when central and peripheral nervous system dysfunction occur concurrently may guide the physician to tissue biopsy facilitating antemortem diagnosis and institution of appropriate therapy.

Duke Scholars

Published In

South Med J

DOI

ISSN

0038-4348

Publication Date

July 1998

Volume

91

Issue

7

Start / End Page

672 / 676

Location

United States

Related Subject Headings

  • Vascular Neoplasms
  • Muscle Weakness
  • Lymphoma, Non-Hodgkin
  • Humans
  • General & Internal Medicine
  • Female
  • Fatal Outcome
  • Diagnosis, Differential
  • Cognition Disorders
  • Biopsy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Devlin, T., Moll, S., Hulette, C., & Morgenlander, J. C. (1998). Intravascular malignant lymphomatosis with neurologic presentation: factors facilitating antemortem diagnosis. South Med J, 91(7), 672–676. https://doi.org/10.1097/00007611-199807000-00015
Devlin, T., S. Moll, C. Hulette, and J. C. Morgenlander. “Intravascular malignant lymphomatosis with neurologic presentation: factors facilitating antemortem diagnosis.South Med J 91, no. 7 (July 1998): 672–76. https://doi.org/10.1097/00007611-199807000-00015.
Devlin T, Moll S, Hulette C, Morgenlander JC. Intravascular malignant lymphomatosis with neurologic presentation: factors facilitating antemortem diagnosis. South Med J. 1998 Jul;91(7):672–6.
Devlin, T., et al. “Intravascular malignant lymphomatosis with neurologic presentation: factors facilitating antemortem diagnosis.South Med J, vol. 91, no. 7, July 1998, pp. 672–76. Pubmed, doi:10.1097/00007611-199807000-00015.
Devlin T, Moll S, Hulette C, Morgenlander JC. Intravascular malignant lymphomatosis with neurologic presentation: factors facilitating antemortem diagnosis. South Med J. 1998 Jul;91(7):672–676.

Published In

South Med J

DOI

ISSN

0038-4348

Publication Date

July 1998

Volume

91

Issue

7

Start / End Page

672 / 676

Location

United States

Related Subject Headings

  • Vascular Neoplasms
  • Muscle Weakness
  • Lymphoma, Non-Hodgkin
  • Humans
  • General & Internal Medicine
  • Female
  • Fatal Outcome
  • Diagnosis, Differential
  • Cognition Disorders
  • Biopsy