Skip to main content

A neural survival factor is a candidate oncogene in breast cancer.

Publication ,  Journal Article
Porter, D; Weremowicz, S; Chin, K; Seth, P; Keshaviah, A; Lahti-Domenici, J; Bae, YK; Monitto, CL; Merlos-Suarez, A; Chan, J; Hulette, CM ...
Published in: Proc Natl Acad Sci U S A
September 16, 2003

Using serial analysis of gene expression (SAGE), we identified a SAGE tag that was present only in invasive breast carcinomas and their lymph node metastases. The transcript corresponding to this SAGE tag, dermcidin (DCD), encodes a secreted protein normally expressed only in the pons of the brain and sweat glands. Array comparative genomic hybridization, fluorescence in situ hybridization, and immunohistochemical analyses determined that DCD is overexpressed in approximately 10% of invasive breast carcinomas; in some cases its overexpression is coupled with a focal copy number gain of its locus at 12q13.1, and its expression is associated with advanced clinical stage and poor prognosis. Expression of DCD in breast cancer cells promotes cell growth and survival and reduces serum dependency. Putative high- and low-affinity receptors for DCD are present on the cell surface of breast carcinomas and neurons of the brain. Based on these data we hypothesize that DCD may play a role in tumorigenesis by means of enhancing cell growth and survival in a subset of breast carcinomas.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

September 16, 2003

Volume

100

Issue

19

Start / End Page

10931 / 10936

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Sequence Homology, Amino Acid
  • Oncogenes
  • Neoplasm Invasiveness
  • Molecular Sequence Data
  • Humans
  • Gene Expression Profiling
  • DNA, Neoplasm
  • Breast Neoplasms
  • Base Sequence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Porter, D., Weremowicz, S., Chin, K., Seth, P., Keshaviah, A., Lahti-Domenici, J., … Polyak, K. (2003). A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A, 100(19), 10931–10936. https://doi.org/10.1073/pnas.1932980100
Porter, Dale, Stanislawa Weremowicz, Koei Chin, Pankaj Seth, Aparna Keshaviah, Jaana Lahti-Domenici, Young Kyung Bae, et al. “A neural survival factor is a candidate oncogene in breast cancer.Proc Natl Acad Sci U S A 100, no. 19 (September 16, 2003): 10931–36. https://doi.org/10.1073/pnas.1932980100.
Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, et al. A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10931–6.
Porter, Dale, et al. “A neural survival factor is a candidate oncogene in breast cancer.Proc Natl Acad Sci U S A, vol. 100, no. 19, Sept. 2003, pp. 10931–36. Pubmed, doi:10.1073/pnas.1932980100.
Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, Bae YK, Monitto CL, Merlos-Suarez A, Chan J, Hulette CM, Richardson A, Morton CC, Marks J, Duyao M, Hruban R, Gabrielson E, Gelman R, Polyak K. A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10931–10936.

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

September 16, 2003

Volume

100

Issue

19

Start / End Page

10931 / 10936

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Sequence Homology, Amino Acid
  • Oncogenes
  • Neoplasm Invasiveness
  • Molecular Sequence Data
  • Humans
  • Gene Expression Profiling
  • DNA, Neoplasm
  • Breast Neoplasms
  • Base Sequence