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Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose

Publication ,  Journal Article
Mori, T; Hatano, K; Matsuoka, K; Esumi, Y; Toone, EJ; Terunuma, D
Published in: Tetrahedron
March 14, 2005
Published version (DOI)

The mannose monosaccharide derivative, acetylthiopropyl 2,3,4,6-tetra-O-acetyl-α-d-mannopyranoside (Man), and the mannobiose derivative, acetylthiopropyl 2,4,6-tri-O-acetyl-3-O-(2′,3′,4′, 6′-tetra-O-acetyl-α-d-mannopyranosyl)-α-d-mannopyranoside (α-1,3-Man), were synthesized respectively. These mannose derivatives were introduced into carbosilane dendrimer scaffolds of the zero and first generations. As a result, six carbosilane dendrimers were functionalized by Man and α-1,3-Man. Isothermal titration microcalorimetry was done to determine binding assay between mannose moieties of carbosilane dendrimer and concanavalin A. It was found that carbosilane dendrimers bound more efficiently to concanavalin A than free mannose (Me-α-Man) and mannobiose (Me-α-1,3-Man). © 2005 Elsevier Ltd. All rights reserved.

Duke Scholars

Eric John Toone
Author Eric John Toone Chemistry

Published In

Tetrahedron

DOI

10.1016/j.tet.2005.01.090

ISSN

0040-4020

Publication Date

March 14, 2005

Volume

61

Issue

11

Start / End Page

2751 / 2760

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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ICMJE
MLA
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Mori, T., Hatano, K., Matsuoka, K., Esumi, Y., Toone, E. J., & Terunuma, D. (2005). Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose. Tetrahedron, 61(11), 2751–2760. https://doi.org/10.1016/j.tet.2005.01.090
Mori, T., K. Hatano, K. Matsuoka, Y. Esumi, E. J. Toone, and D. Terunuma. “Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose.” Tetrahedron 61, no. 11 (March 14, 2005): 2751–60. https://doi.org/10.1016/j.tet.2005.01.090.
Mori T, Hatano K, Matsuoka K, Esumi Y, Toone EJ, Terunuma D. Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose. Tetrahedron. 2005 Mar 14;61(11):2751–60.
Mori, T., et al. “Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose.” Tetrahedron, vol. 61, no. 11, Mar. 2005, pp. 2751–60. Scopus, doi:10.1016/j.tet.2005.01.090.
Mori T, Hatano K, Matsuoka K, Esumi Y, Toone EJ, Terunuma D. Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose. Tetrahedron. 2005 Mar 14;61(11):2751–2760.
Journal cover image

Published In

Tetrahedron

DOI

10.1016/j.tet.2005.01.090

ISSN

0040-4020

Publication Date

March 14, 2005

Volume

61

Issue

11

Start / End Page

2751 / 2760

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry