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CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition.

Publication ,  Journal Article
Ferrari, G; Neal, W; Jones, A; Olender, N; Ottinger, J; Ha, R; McElrath, MJ; Goepfert, P; Weinhold, KJ
Published in: Immunol Lett
November 1, 2001

We evaluated MHC-class I-restricted CTL responses induced by HIV-1 clade B-based vaccines in nine HIV-1 seronegative vaccine recipients with regard to their patterns of HLA restriction and epitope recognition. We found that seven of nine volunteers developed detectable CTL reactivities against novel epitopes within the HIV-1 Env and Gag proteins. Although four of nine subjects were HLA-A*0201, none of the cellular responses was restricted in the context of this allele. The type of responses observed in this sampling of vaccines appeared similar to those reported during primary infection and among long term non-progressors, with three out of nine subjects recognizing HLA-B27 or HLA-B17(57)-restricted epitopes. Although the majority of CTL responses were directed against novel epitopes, these effectors were still able to mediate cross-clade reactivities.

Duke Scholars

Published In

Immunol Lett

DOI

ISSN

0165-2478

Publication Date

November 1, 2001

Volume

79

Issue

1-2

Start / End Page

37 / 45

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes, Cytotoxic
  • Immunology
  • Humans
  • HLA Antigens
  • HIV-1
  • HIV Seronegativity
  • HIV Antigens
  • Gene Products, gag
  • Gene Products, env
  • Epitopes
 

Citation

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MLA
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Ferrari, G., Neal, W., Jones, A., Olender, N., Ottinger, J., Ha, R., … Weinhold, K. J. (2001). CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition. Immunol Lett, 79(1–2), 37–45. https://doi.org/10.1016/s0165-2478(01)00264-4
Ferrari, G., W. Neal, A. Jones, N. Olender, J. Ottinger, R. Ha, M. J. McElrath, P. Goepfert, and K. J. Weinhold. “CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition.Immunol Lett 79, no. 1–2 (November 1, 2001): 37–45. https://doi.org/10.1016/s0165-2478(01)00264-4.
Ferrari G, Neal W, Jones A, Olender N, Ottinger J, Ha R, et al. CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition. Immunol Lett. 2001 Nov 1;79(1–2):37–45.
Ferrari, G., et al. “CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition.Immunol Lett, vol. 79, no. 1–2, Nov. 2001, pp. 37–45. Pubmed, doi:10.1016/s0165-2478(01)00264-4.
Ferrari G, Neal W, Jones A, Olender N, Ottinger J, Ha R, McElrath MJ, Goepfert P, Weinhold KJ. CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition. Immunol Lett. 2001 Nov 1;79(1–2):37–45.
Journal cover image

Published In

Immunol Lett

DOI

ISSN

0165-2478

Publication Date

November 1, 2001

Volume

79

Issue

1-2

Start / End Page

37 / 45

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes, Cytotoxic
  • Immunology
  • Humans
  • HLA Antigens
  • HIV-1
  • HIV Seronegativity
  • HIV Antigens
  • Gene Products, gag
  • Gene Products, env
  • Epitopes