Skip to main content
Journal cover image

Comparative genomics as a tool for gene discovery.

Publication ,  Journal Article
Windsor, AJ; Mitchell-Olds, T
Published in: Current opinion in biotechnology
April 2006

With the increasing availability of data from multiple eukaryotic genome sequencing projects, attention has focused on interspecific comparisons to discover novel genes and transcribed genomic sequences. Generally, these extrinsic strategies combine ab initio gene prediction with expression and/or homology data to identify conserved gene candidates between two or more genomes. Interspecific sequence analyses have proven invaluable for the improvement of existing annotations, automation of annotation, and identification of novel coding regions and splice variants. Further, comparative genomic approaches hold the promise of improved prediction of terminal or small exons, microRNA precursors, and small peptide-encoding open reading frames--sequence elements that are difficult to identify through purely intrinsic methodologies in the absence of experimental data.

Duke Scholars

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

April 2006

Volume

17

Issue

2

Start / End Page

161 / 167

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Predictive Value of Tests
  • Models, Genetic
  • Genomics
  • Genes, Plant
  • Conserved Sequence
  • Computational Biology
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Windsor, A. J., & Mitchell-Olds, T. (2006). Comparative genomics as a tool for gene discovery. Current Opinion in Biotechnology, 17(2), 161–167. https://doi.org/10.1016/j.copbio.2006.01.007
Windsor, Aaron J., and Thomas Mitchell-Olds. “Comparative genomics as a tool for gene discovery.Current Opinion in Biotechnology 17, no. 2 (April 2006): 161–67. https://doi.org/10.1016/j.copbio.2006.01.007.
Windsor AJ, Mitchell-Olds T. Comparative genomics as a tool for gene discovery. Current opinion in biotechnology. 2006 Apr;17(2):161–7.
Windsor, Aaron J., and Thomas Mitchell-Olds. “Comparative genomics as a tool for gene discovery.Current Opinion in Biotechnology, vol. 17, no. 2, Apr. 2006, pp. 161–67. Epmc, doi:10.1016/j.copbio.2006.01.007.
Windsor AJ, Mitchell-Olds T. Comparative genomics as a tool for gene discovery. Current opinion in biotechnology. 2006 Apr;17(2):161–167.
Journal cover image

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

April 2006

Volume

17

Issue

2

Start / End Page

161 / 167

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Predictive Value of Tests
  • Models, Genetic
  • Genomics
  • Genes, Plant
  • Conserved Sequence
  • Computational Biology
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology