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Molecular typing of pathogenic fungi.

Publication ,  Journal Article
McEwen, JG; Taylor, JW; Carter, D; Xu, J; Felipe, MS; Vilgalys, R; Mitchell, TG; Kasuga, T; White, T; Bui, T; Soares, CM
Published in: Med Mycol
2000

In this Round Table, the application of several methods of molecular typing were discussed in reference to four important pathogenic fungi: Coccidioides immitis, Histoplasma capsulatum, Candida albicans and Paracoccidioides brasiliensis. Among the different methods the following were discussed: restriction fragment length polymorphisms (RFLP), single nucleotide polymorphisms, random amplified polymorphic DNA (RAPD), polymerase chain reaction (PCR)-RFLP and microsatellites. By means of these methods, several important biological questions related to speciation, mode of reproduction and population genetics could be approached. The basic information obtained from this approach has implications in the understanding of these pathogenic fungi in relation to their behavior and the development of pathogenic features, such as resistance to antimicrobials and virulence factors used for colonization of mammalian hosts. The knowledge obtained from these studies could also be used for the development of innovative diagnostic methods, as well as for novel therapeutic approaches and production of vaccines.

Duke Scholars

Published In

Med Mycol

ISSN

1369-3786

Publication Date

2000

Volume

38 Suppl 1

Start / End Page

189 / 197

Location

England

Related Subject Headings

  • Mycoses
  • Mycological Typing Techniques
  • Mitosporic Fungi
  • Microbiology
  • Humans
  • Genetic Techniques
  • 3207 Medical microbiology
  • 3202 Clinical sciences
  • 3107 Microbiology
  • 1108 Medical Microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McEwen, J. G., Taylor, J. W., Carter, D., Xu, J., Felipe, M. S., Vilgalys, R., … Soares, C. M. (2000). Molecular typing of pathogenic fungi. Med Mycol, 38 Suppl 1, 189–197.
McEwen, J. G., J. W. Taylor, D. Carter, J. Xu, M. S. Felipe, R. Vilgalys, T. G. Mitchell, et al. “Molecular typing of pathogenic fungi.Med Mycol 38 Suppl 1 (2000): 189–97.
McEwen JG, Taylor JW, Carter D, Xu J, Felipe MS, Vilgalys R, et al. Molecular typing of pathogenic fungi. Med Mycol. 2000;38 Suppl 1:189–97.
McEwen, J. G., et al. “Molecular typing of pathogenic fungi.Med Mycol, vol. 38 Suppl 1, 2000, pp. 189–97.
McEwen JG, Taylor JW, Carter D, Xu J, Felipe MS, Vilgalys R, Mitchell TG, Kasuga T, White T, Bui T, Soares CM. Molecular typing of pathogenic fungi. Med Mycol. 2000;38 Suppl 1:189–197.

Published In

Med Mycol

ISSN

1369-3786

Publication Date

2000

Volume

38 Suppl 1

Start / End Page

189 / 197

Location

England

Related Subject Headings

  • Mycoses
  • Mycological Typing Techniques
  • Mitosporic Fungi
  • Microbiology
  • Humans
  • Genetic Techniques
  • 3207 Medical microbiology
  • 3202 Clinical sciences
  • 3107 Microbiology
  • 1108 Medical Microbiology