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FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.

Publication ,  Journal Article
Xu, X; Su, B; Barndt, RJ; Chen, H; Xin, H; Yan, G; Chen, L; Cheng, D; Heitman, J; Zhuang, Y; Fleischer, S; Shou, W
Published in: Transplantation
June 15, 2002

BACKGROUND: FK506-binding proteins (FKBP) are immunophilins that interact with the immunosuppressive drugs FK506 and rapamycin. Several FKBP family members such as FKBP12, FKBP12.6, and FKBP51 are expressed in T cells. It has been speculated that these FKBPs are possibly redundant in the immunosuppressant-induced T-cell inactivation. To determine the pharmacological relevance of multiple FKBP members in the immunosuppressant-induced T-cell inactivation, we have investigated the physiological responses of FKBP12-deficient and FKBP12.6-deficient mutant T cells to the immunosuppressive agent FK506. METHODS: FKBP12-deficient and FKBP12.6-deficient T cells were isolated from genetically engineered FKBP12-deficient and FKBP12.6-deficient mice, respectively. T-cell growth inhibitory assay was used to assess their responses to immunosuppressant FK506 treatments. RESULTS: We found that growth inhibition induced by FK506 is abolished in FKBP12-deficient cells but not in FKBP12.6-deficient cells. CONCLUSIONS: FKBP12 is the only FKBP family member that plays a key role in immunosuppressant-mediated immunosuppression.

Duke Scholars

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Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

June 15, 2002

Volume

73

Issue

11

Start / End Page

1835 / 1838

Location

United States

Related Subject Headings

  • Tacrolimus Binding Protein 1A
  • Tacrolimus
  • T-Lymphocytes
  • Surgery
  • Mice, Knockout
  • Mice
  • Immunosuppressive Agents
  • Dose-Response Relationship, Drug
  • Cyclosporine
  • Cell Division
 

Citation

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Xu, X., Su, B., Barndt, R. J., Chen, H., Xin, H., Yan, G., … Shou, W. (2002). FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. Transplantation, 73(11), 1835–1838. https://doi.org/10.1097/00007890-200206150-00023
Xu, Xuehong, Bing Su, Robert J. Barndt, Hanying Chen, Hongbo Xin, Guifan Yan, Linyuan Chen, et al. “FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.Transplantation 73, no. 11 (June 15, 2002): 1835–38. https://doi.org/10.1097/00007890-200206150-00023.
Xu X, Su B, Barndt RJ, Chen H, Xin H, Yan G, et al. FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. Transplantation. 2002 Jun 15;73(11):1835–8.
Xu, Xuehong, et al. “FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.Transplantation, vol. 73, no. 11, June 2002, pp. 1835–38. Pubmed, doi:10.1097/00007890-200206150-00023.
Xu X, Su B, Barndt RJ, Chen H, Xin H, Yan G, Chen L, Cheng D, Heitman J, Zhuang Y, Fleischer S, Shou W. FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. Transplantation. 2002 Jun 15;73(11):1835–1838.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

June 15, 2002

Volume

73

Issue

11

Start / End Page

1835 / 1838

Location

United States

Related Subject Headings

  • Tacrolimus Binding Protein 1A
  • Tacrolimus
  • T-Lymphocytes
  • Surgery
  • Mice, Knockout
  • Mice
  • Immunosuppressive Agents
  • Dose-Response Relationship, Drug
  • Cyclosporine
  • Cell Division