Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

A genetic investigation of E2A function in lymphocyte development.

Publication ,  Journal Article
Hanrahan, J; Pan, L; Greenbaum, S; Bradney, C; Hjelmeland, M; Dai, M; Zhuang, Y
Published in: Immunol Res
2000

Lymphocytes are derived from hematopoietic stem cells (HSC) following a series of regulated differentiation events. Multipotent HSCs become committed to the B cell lineage in bone marrow and the T cell lineage in the thymus after receiving appropriate signals from the corresponding microenvironment. These committed lymphoid cells must then undergo V(D)J recombination at the immunoglobulin gene or T cell receptor gene locus resulting in clonal production of functional B or T lymphocytes, respectively. Lymphocyte commitment and differentiation are accompanied by programmed gene expression or repression events which are driven by lineage and stage specific transcription factors. The basic-helix-loop-helix (bHLH) transcription factors encoded by the E2A gene are involved in several differentiation events during B and T cell development, including lineage commitment, initiation of V(D)J recombination, and antigen receptor mediated proliferation and differentiation. Several recent reviews have provided a comprehensive discussion of biochemical, cellular, and genetic research on E2A function in lymphocyte development (1,2). Here, we only discuss some of the genetic approaches our laboratory (except where it is noted) has undertaken to investigate the molecular pathways mediated by E2A transcription factors in lymphocyte development.

Duke Scholars

Published In

Immunol Res

DOI

ISSN

0257-277X

Publication Date

2000

Volume

22

Issue

2-3

Start / End Page

211 / 222

Location

United States

Related Subject Headings

  • Transcription Factors
  • T-Lymphocytes
  • Lymphocytes
  • Immunology
  • Humans
  • Helix-Loop-Helix Motifs
  • DNA-Binding Proteins
  • Cell Differentiation
  • Basic Helix-Loop-Helix Transcription Factors
  • B-Lymphocytes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hanrahan, J., Pan, L., Greenbaum, S., Bradney, C., Hjelmeland, M., Dai, M., & Zhuang, Y. (2000). A genetic investigation of E2A function in lymphocyte development. Immunol Res, 22(2–3), 211–222. https://doi.org/10.1385/ir:22:2-3:211
Hanrahan, J., L. Pan, S. Greenbaum, C. Bradney, M. Hjelmeland, M. Dai, and Y. Zhuang. “A genetic investigation of E2A function in lymphocyte development.Immunol Res 22, no. 2–3 (2000): 211–22. https://doi.org/10.1385/ir:22:2-3:211.
Hanrahan J, Pan L, Greenbaum S, Bradney C, Hjelmeland M, Dai M, et al. A genetic investigation of E2A function in lymphocyte development. Immunol Res. 2000;22(2–3):211–22.
Hanrahan, J., et al. “A genetic investigation of E2A function in lymphocyte development.Immunol Res, vol. 22, no. 2–3, 2000, pp. 211–22. Pubmed, doi:10.1385/ir:22:2-3:211.
Hanrahan J, Pan L, Greenbaum S, Bradney C, Hjelmeland M, Dai M, Zhuang Y. A genetic investigation of E2A function in lymphocyte development. Immunol Res. 2000;22(2–3):211–222.
Journal cover image

Published In

Immunol Res

DOI

ISSN

0257-277X

Publication Date

2000

Volume

22

Issue

2-3

Start / End Page

211 / 222

Location

United States

Related Subject Headings

  • Transcription Factors
  • T-Lymphocytes
  • Lymphocytes
  • Immunology
  • Humans
  • Helix-Loop-Helix Motifs
  • DNA-Binding Proteins
  • Cell Differentiation
  • Basic Helix-Loop-Helix Transcription Factors
  • B-Lymphocytes