
New insights into E-protein function in lymphocyte development.
Lymphocyte development has long served as an experimental paradigm, revealing fundamental mechanisms of gene regulation and cellular differentiation in mammals. The study of E-protein-mediated transcriptional regulation in lymphocyte development provides a means to address these mechanistic issues. Both genetic and biochemical studies have defined many important regulatory events during lymphocyte development that are mediated by E-proteins. The E2A gene, one of the three known E-protein genes in mammals, has a particularly important role in B-lymphocyte development. Major progress has been made in recent years towards understanding the physiological targets of E2A during B-lymphocyte development. Most notably, new insights have been gained regarding the role of E2A in controlling lineage commitment and V(D)J recombination. This Review focuses primarily on E2A-mediated gene regulation during B-lymphocyte development.
Duke Scholars
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Related Subject Headings
- Transcription Factors
- Lymphocytes
- Immunology
- Immunoglobulin kappa-Chains
- Humans
- Gene Expression Regulation
- DNA-Binding Proteins
- Cell Lineage
- Cell Differentiation
- Basic Helix-Loop-Helix Transcription Factors
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Transcription Factors
- Lymphocytes
- Immunology
- Immunoglobulin kappa-Chains
- Humans
- Gene Expression Regulation
- DNA-Binding Proteins
- Cell Lineage
- Cell Differentiation
- Basic Helix-Loop-Helix Transcription Factors