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HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients.

Publication ,  Journal Article
Buckley, CE; White, DH; Seigler, HF
Published in: Monogr Allergy
1977

Cutaneous responses to tuberculin and control antigens were measured in 24 HLA-B7 and 39 non-B7 patients before and 5-44 (average 10.5) weeks after BCG immunotherapy for malignant melanoma. Delayed tuberculin hypersensitivity increased after immunotherapy (p less than or equal 0.0001). The averaged area of induration (48 h) detected in HLA-B7 patients was half the area of induration of non-B7 patients before (p less than or equal to 0.0184) and after (p less than or equal to 0.0007) BCG treatment. Cutaneous anaphylactic hypersensitivity (0.25 h) responses to 19 of 22 antigens were significantly smaller (p less than 0.05) in HLA-B7 patients after BCG immunotherapy (p less than or equal to 0.0001). HLA-B7 patients had specific delayed cutaneous hyporesponsiveness to tuberculin and nonspecific cutaneous anaphylactic hyporesponsiveness after BCG immunotherapy.

Duke Scholars

Published In

Monogr Allergy

ISSN

0077-0760

Publication Date

1977

Volume

11

Start / End Page

97 / 105

Location

Switzerland

Related Subject Headings

  • Tuberculin Test
  • Phenotype
  • Melanoma
  • Immunosuppression Therapy
  • Humans
  • Histocompatibility Antigens
  • HLA Antigens
  • BCG Vaccine
  • Antibody Formation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Buckley, C. E., White, D. H., & Seigler, H. F. (1977). HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients. Monogr Allergy, 11, 97–105.
Buckley, C. E., D. H. White, and H. F. Seigler. “HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients.Monogr Allergy 11 (1977): 97–105.
Buckley CE, White DH, Seigler HF. HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients. Monogr Allergy. 1977;11:97–105.
Buckley, C. E., et al. “HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients.Monogr Allergy, vol. 11, 1977, pp. 97–105.
Buckley CE, White DH, Seigler HF. HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients. Monogr Allergy. 1977;11:97–105.

Published In

Monogr Allergy

ISSN

0077-0760

Publication Date

1977

Volume

11

Start / End Page

97 / 105

Location

Switzerland

Related Subject Headings

  • Tuberculin Test
  • Phenotype
  • Melanoma
  • Immunosuppression Therapy
  • Humans
  • Histocompatibility Antigens
  • HLA Antigens
  • BCG Vaccine
  • Antibody Formation