Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Intracerebroventricular neuropeptide Y increases gastric acid secretion by decreasing tonic adrenergic inhibition of acid in dogs.

Publication ,  Journal Article
Geoghegan, JG; Lawson, DC; Cheng, CA; Pappas, TN
Published in: Brain Res
January 28, 1994

Neuropeptide Y (NPY) has been shown to increase basal gastric acid secretion in dogs. We examined the hypothesis that NPY might increase gastric acid secretion by interaction with central catecholaminergic control of acid secretion in dogs. Studies were performed in awake canines with gastric fistulas and cerebroventricular guides which allowed injection into the lateral cerebral ventricle. Intracerebroventricular (i.c.v.) injection of yohimbine (5 micrograms/kg) increased acid secretion compared to control (yohimbine: 9.1 +/- 3.3 mmol/h; control: 1.8 +/- 1.0 mmol/2 h P < 0.05), whereas prazosin and propranolol (both 5 micrograms/kg i.c.v.) had no effect, suggesting that there is tonic central alpha 2-adrenergic inhibition of acid secretion. NPY13-36 significantly increased acid secretion compared to control (NPY13-36 1000 pmol/kg i.c.v.: 5.6 +/- 1.9 mmol/2 h; control: 1.3 +/- 0.8 mmol/2 h, P < 0.05), whereas [Leu31,Pro34]-NPY had no effect, suggesting that the central effect of NPY is mediated at a Y2, probably pre-synaptic receptor. Finally, i.c.v. desmethylimipramine (DMI) inhibited the acid response to i.c.v. NPY when injected before but not after NPY (i.c.v. DMI then i.c.v. NPY: control, 15.2 +/- 6.6 mmol/2 h; DMI, 3.5 +/- 1.2 mmol/2 h, P < 0.05; i.c.v. NPY followed by i.c.v. DMI: control, 8.9 +/- 4.0 mmol/2 h; DMI, 9.9 +/- 2.9 mmol/2 h, P > 0.05). This suggests that NPY acts by decreasing noradrenaline release. These findings are compatible with the hypothesis that i.c.v. NPY increases acid secretion by decreasing tonic central adrenergic inhibition of acid by decreasing release of noradrenaline at a pre-synaptic level.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

January 28, 1994

Volume

635

Issue

1-2

Start / End Page

118 / 124

Location

Netherlands

Related Subject Headings

  • Receptors, Neuropeptide Y
  • Peptide Fragments
  • Neuropeptide Y
  • Neurology & Neurosurgery
  • Male
  • Injections, Intraventricular
  • Gastric Acid
  • Female
  • Dogs
  • Desipramine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Geoghegan, J. G., Lawson, D. C., Cheng, C. A., & Pappas, T. N. (1994). Intracerebroventricular neuropeptide Y increases gastric acid secretion by decreasing tonic adrenergic inhibition of acid in dogs. Brain Res, 635(1–2), 118–124. https://doi.org/10.1016/0006-8993(94)91430-3
Geoghegan, J. G., D. C. Lawson, C. A. Cheng, and T. N. Pappas. “Intracerebroventricular neuropeptide Y increases gastric acid secretion by decreasing tonic adrenergic inhibition of acid in dogs.Brain Res 635, no. 1–2 (January 28, 1994): 118–24. https://doi.org/10.1016/0006-8993(94)91430-3.
Geoghegan JG, Lawson DC, Cheng CA, Pappas TN. Intracerebroventricular neuropeptide Y increases gastric acid secretion by decreasing tonic adrenergic inhibition of acid in dogs. Brain Res. 1994 Jan 28;635(1–2):118–24.
Geoghegan, J. G., et al. “Intracerebroventricular neuropeptide Y increases gastric acid secretion by decreasing tonic adrenergic inhibition of acid in dogs.Brain Res, vol. 635, no. 1–2, Jan. 1994, pp. 118–24. Pubmed, doi:10.1016/0006-8993(94)91430-3.
Geoghegan JG, Lawson DC, Cheng CA, Pappas TN. Intracerebroventricular neuropeptide Y increases gastric acid secretion by decreasing tonic adrenergic inhibition of acid in dogs. Brain Res. 1994 Jan 28;635(1–2):118–124.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

January 28, 1994

Volume

635

Issue

1-2

Start / End Page

118 / 124

Location

Netherlands

Related Subject Headings

  • Receptors, Neuropeptide Y
  • Peptide Fragments
  • Neuropeptide Y
  • Neurology & Neurosurgery
  • Male
  • Injections, Intraventricular
  • Gastric Acid
  • Female
  • Dogs
  • Desipramine