
Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure.
Publication
, Journal Article
Spence, AM; Berger, MS; Livingston, RB; Ali-Osman, F; Griffin, B
Published in: J Neurooncol
February 1992
Twenty-one patients with recurrent malignant glioma who had failed prior chemotherapy with nitrosoureas were treated with high-dose intravenous cisplatin on days 1 and 8 of successive 4 week cycles. Fourteen patients were evaluable for response. Four patients showed partial responses; mean time to tumor progression (MTP) was 8 weeks. Six patients stabilized; MTP was 11 weeks. Four patients showed no response. There were no infectious or hemorrhagic complications, but partial hearing loss occurred in 7 patients and severe vomiting in 8 patients. High-dose intravenous cisplatin demonstrates substantial activity against malignant gliomas recurrent after chloroethylnitrosourea (CENU) failure.
Duke Scholars
Published In
J Neurooncol
DOI
ISSN
0167-594X
Publication Date
February 1992
Volume
12
Issue
2
Start / End Page
187 / 191
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Nitroso Compounds
- Neoplasm Recurrence, Local
- Middle Aged
- Male
- Infusions, Intravenous
- Humans
- Glioma
- Female
- Drug Evaluation
Citation
APA
Chicago
ICMJE
MLA
NLM
Spence, A. M., Berger, M. S., Livingston, R. B., Ali-Osman, F., & Griffin, B. (1992). Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure. J Neurooncol, 12(2), 187–191. https://doi.org/10.1007/BF00172671
Spence, A. M., M. S. Berger, R. B. Livingston, F. Ali-Osman, and B. Griffin. “Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure.” J Neurooncol 12, no. 2 (February 1992): 187–91. https://doi.org/10.1007/BF00172671.
Spence AM, Berger MS, Livingston RB, Ali-Osman F, Griffin B. Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure. J Neurooncol. 1992 Feb;12(2):187–91.
Spence, A. M., et al. “Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure.” J Neurooncol, vol. 12, no. 2, Feb. 1992, pp. 187–91. Pubmed, doi:10.1007/BF00172671.
Spence AM, Berger MS, Livingston RB, Ali-Osman F, Griffin B. Phase II evaluation of high-dose intravenous cisplatin for treatment of adult malignant gliomas recurrent after chloroethylnitrosourea failure. J Neurooncol. 1992 Feb;12(2):187–191.

Published In
J Neurooncol
DOI
ISSN
0167-594X
Publication Date
February 1992
Volume
12
Issue
2
Start / End Page
187 / 191
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Nitroso Compounds
- Neoplasm Recurrence, Local
- Middle Aged
- Male
- Infusions, Intravenous
- Humans
- Glioma
- Female
- Drug Evaluation