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Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.

Publication ,  Journal Article
Davidoff, AM; Iglehart, JD; Marks, JR
Published in: Proc Natl Acad Sci U S A
April 15, 1992

Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to the p53 protein. In this study, the anti-p53 humoral response is correlated with the presence and type of mutant p53 protein expressed in the tumor. In a series of 60 breast cancer patients, 0 of 30 tumors with normal, low-level p53 expression induced anti-p53 antibodies, whereas 7 (23%) of 30 tumors with p53 overexpression elicited a specific anti-p53 antibody response. These 7 patients had anti-p53 antibodies that recognized wild-type p53 and a variety of mutant p53 proteins. A comparison of p53 mutations revealed that antibody-negative tumors had mutations exclusively in exons 7 and 8, whereas antibody-positive tumors had mutations primarily in exons 5 and 6. Moreover, all antibody-eliciting tumors contained complexes between p53 and a 70-kDa heat shock protein, whereas none of the antibody-negative tumors contained this complex. This study implicates a 70-kDa heat shock protein in the antigenic presentation of p53.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

April 15, 1992

Volume

89

Issue

8

Start / End Page

3439 / 3442

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • RNA, Messenger
  • Mutation
  • Methionine
  • Immunoblotting
  • Humans
  • Heat-Shock Proteins
  • Genes, p53
  • Female
  • Epitopes
 

Citation

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Davidoff, A. M., Iglehart, J. D., & Marks, J. R. (1992). Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers. Proc Natl Acad Sci U S A, 89(8), 3439–3442. https://doi.org/10.1073/pnas.89.8.3439
Davidoff, A. M., J. D. Iglehart, and J. R. Marks. “Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.Proc Natl Acad Sci U S A 89, no. 8 (April 15, 1992): 3439–42. https://doi.org/10.1073/pnas.89.8.3439.
Davidoff AM, Iglehart JD, Marks JR. Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3439–42.
Davidoff, A. M., et al. “Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.Proc Natl Acad Sci U S A, vol. 89, no. 8, Apr. 1992, pp. 3439–42. Pubmed, doi:10.1073/pnas.89.8.3439.
Davidoff AM, Iglehart JD, Marks JR. Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3439–3442.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

April 15, 1992

Volume

89

Issue

8

Start / End Page

3439 / 3442

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • RNA, Messenger
  • Mutation
  • Methionine
  • Immunoblotting
  • Humans
  • Heat-Shock Proteins
  • Genes, p53
  • Female
  • Epitopes