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Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.

Publication ,  Journal Article
Mu, D; Chen, L; Zhang, X; See, L-H; Koch, CM; Yen, C; Tong, JJ; Spiegel, L; Nguyen, KCQ; Servoss, A; Peng, Y; Pei, L; Marks, JR; Lowe, S ...
Published in: Cancer Cell
March 2003

Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.

Duke Scholars

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Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

March 2003

Volume

3

Issue

3

Start / End Page

297 / 302

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Sequence Tagged Sites
  • Potassium Channels
  • Physical Chromosome Mapping
  • Oncology & Carcinogenesis
  • Oncogenes
  • Molecular Sequence Data
  • Mice
  • Humans
  • Genome, Human
 

Citation

APA
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Mu, D., Chen, L., Zhang, X., See, L.-H., Koch, C. M., Yen, C., … Powers, S. (2003). Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3(3), 297–302. https://doi.org/10.1016/s1535-6108(03)00054-0
Mu, David, Liyun Chen, Xiping Zhang, Lei-Hoon See, Christina M. Koch, Clifford Yen, James Jiayuan Tong, et al. “Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.Cancer Cell 3, no. 3 (March 2003): 297–302. https://doi.org/10.1016/s1535-6108(03)00054-0.
Mu D, Chen L, Zhang X, See L-H, Koch CM, Yen C, et al. Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell. 2003 Mar;3(3):297–302.
Mu, David, et al. “Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.Cancer Cell, vol. 3, no. 3, Mar. 2003, pp. 297–302. Pubmed, doi:10.1016/s1535-6108(03)00054-0.
Mu D, Chen L, Zhang X, See L-H, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KCQ, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, Jan LY, McCombie WR, Wigler MH, Powers S. Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell. 2003 Mar;3(3):297–302.

Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

March 2003

Volume

3

Issue

3

Start / End Page

297 / 302

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Sequence Tagged Sites
  • Potassium Channels
  • Physical Chromosome Mapping
  • Oncology & Carcinogenesis
  • Oncogenes
  • Molecular Sequence Data
  • Mice
  • Humans
  • Genome, Human