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Vincristine therapy for severe platelet alloimmunization.

Publication ,  Journal Article
Bruggers, CS; Kurtzberg, J; Friedman, HS
Published in: Am J Pediatr Hematol Oncol
1991

A 19-month-old girl with idiopathic severe aplastic anemia refractory to multi-agent immunosuppressive therapy developed severe platelet alloimmunization following several months of platelet transfusions. She became refractory to human leukocyte antigen (HLA)-matched platelet transfusions and experienced frequent episodes of bleeding. She was treated with intravenous vincristine administered weekly for three doses and showed marked improvement in both clinical and laboratory response to platelet transfusions. When vincristine was held for 3 weeks, she again became refractory to HLA-matched platelet transfusion. Reinstitution of vincristine resulted in cessation of clinical bleeding and improved response to platelet transfusion. The mechanism of response likely involves selective delivery of cytotoxic drug to macrophages. To our knowledge this is the first reported case of alloimmune thrombocytopenia responsive to vincristine.

Duke Scholars

Published In

Am J Pediatr Hematol Oncol

DOI

ISSN

0192-8562

Publication Date

1991

Volume

13

Issue

3

Start / End Page

300 / 304

Location

United States

Related Subject Headings

  • Vincristine
  • Transfusion Reaction
  • Thrombocytopenia
  • T-Lymphocytes
  • Prednisone
  • Platelet Transfusion
  • Pancytopenia
  • Megakaryocytes
  • Macrophages
  • Isoantibodies
 

Citation

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Bruggers, C. S., Kurtzberg, J., & Friedman, H. S. (1991). Vincristine therapy for severe platelet alloimmunization. Am J Pediatr Hematol Oncol, 13(3), 300–304. https://doi.org/10.1097/00043426-199123000-00009
Bruggers, C. S., J. Kurtzberg, and H. S. Friedman. “Vincristine therapy for severe platelet alloimmunization.Am J Pediatr Hematol Oncol 13, no. 3 (1991): 300–304. https://doi.org/10.1097/00043426-199123000-00009.
Bruggers CS, Kurtzberg J, Friedman HS. Vincristine therapy for severe platelet alloimmunization. Am J Pediatr Hematol Oncol. 1991;13(3):300–4.
Bruggers, C. S., et al. “Vincristine therapy for severe platelet alloimmunization.Am J Pediatr Hematol Oncol, vol. 13, no. 3, 1991, pp. 300–04. Pubmed, doi:10.1097/00043426-199123000-00009.
Bruggers CS, Kurtzberg J, Friedman HS. Vincristine therapy for severe platelet alloimmunization. Am J Pediatr Hematol Oncol. 1991;13(3):300–304.

Published In

Am J Pediatr Hematol Oncol

DOI

ISSN

0192-8562

Publication Date

1991

Volume

13

Issue

3

Start / End Page

300 / 304

Location

United States

Related Subject Headings

  • Vincristine
  • Transfusion Reaction
  • Thrombocytopenia
  • T-Lymphocytes
  • Prednisone
  • Platelet Transfusion
  • Pancytopenia
  • Megakaryocytes
  • Macrophages
  • Isoantibodies