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Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein.

Publication ,  Journal Article
Nashold, JR; Oakes, WJ; Friedman, HS; Halperin, EC; Soo, M; Hockenberger, B; Fuller, GN; Tien, R
Published in: Med Pediatr Oncol
1994

A 16-year-old white male presented with multiple abnormal extraocular movements secondary to an enhancing pineal tumor. Subtotal resection of the lesion revealed a mixed malignant germ cell tumor. The preoperative serum alpha-fetoprotein (AFP) was markedly elevated at 155 IU/L. The patient subsequently received radiotherapy and adjuvant chemotherapy consisting of cisplatin rotating monthly with vincristine and cyclophosphamide, with dramatic tumor regression and return of AFP to normal. Eighteen months later the persistence of a substantial tumor mass despite a normal AFP raised concern for residual active tumor. Histological examination of the resected lesion revealed benign teratoma and fibrous tissue. Repeat management of mixed malignant germ cell tumors, which demonstrate a persistent mass following an initial response to treatment.

Duke Scholars

Published In

Med Pediatr Oncol

DOI

ISSN

0098-1532

Publication Date

1994

Volume

22

Issue

2

Start / End Page

137 / 139

Location

United States

Related Subject Headings

  • alpha-Fetoproteins
  • Vincristine
  • Teratoma
  • Reoperation
  • Pineal Gland
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • Germinoma
  • Cyclophosphamide
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nashold, J. R., Oakes, W. J., Friedman, H. S., Halperin, E. C., Soo, M., Hockenberger, B., … Tien, R. (1994). Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein. Med Pediatr Oncol, 22(2), 137–139. https://doi.org/10.1002/mpo.2950220215
Nashold, J. R., W. J. Oakes, H. S. Friedman, E. C. Halperin, M. Soo, B. Hockenberger, G. N. Fuller, and R. Tien. “Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein.Med Pediatr Oncol 22, no. 2 (1994): 137–39. https://doi.org/10.1002/mpo.2950220215.
Nashold JR, Oakes WJ, Friedman HS, Halperin EC, Soo M, Hockenberger B, et al. Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein. Med Pediatr Oncol. 1994;22(2):137–9.
Nashold, J. R., et al. “Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein.Med Pediatr Oncol, vol. 22, no. 2, 1994, pp. 137–39. Pubmed, doi:10.1002/mpo.2950220215.
Nashold JR, Oakes WJ, Friedman HS, Halperin EC, Soo M, Hockenberger B, Fuller GN, Tien R. Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein. Med Pediatr Oncol. 1994;22(2):137–139.

Published In

Med Pediatr Oncol

DOI

ISSN

0098-1532

Publication Date

1994

Volume

22

Issue

2

Start / End Page

137 / 139

Location

United States

Related Subject Headings

  • alpha-Fetoproteins
  • Vincristine
  • Teratoma
  • Reoperation
  • Pineal Gland
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • Germinoma
  • Cyclophosphamide