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Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders.

Publication ,  Journal Article
Iacono, RP; Kuniyoshi, SM; Ahlman, JR; Zimmerman, GJ; Maeda, G; Pearlstein, RD
Published in: J Neural Transm (Vienna)
1997

Postural instability and gait disorders (PIGD) are the primary causes of disability in many but not all advanced Parkinson's disease (PD) patients. We have measured the concentrations of serotonin, 5-hydroxytryptophan (5-HTP), 5-hydroxy-3-indoleacetic acid (5-HIAA), and homovanillic acid (HVA) in samples of ventricular cerebrospinal fluid from ten PD patients with severe disability from PIGD and from ten PD patients with tremor and levodopa induced dyskinesia as their predominant motor dysfunction. The two groups were prospectively matched for duration of disease and age. No significant differences between the two groups were found in the concentration (mean +/- SD in ng/ml, PIGD dominant vs. tremor-dyskinesia dominant) of 5-HIAA (106 +/- 50 vs. 99 +/- 34) or HVA (1,068 +/- 595 vs. 881 +/- 469). Serotonin concentration was significantly lower (0.7 +/- 0.5 vs. 1.5 +/- 0.9) and 5-HTP concentration was substantially higher (684 +/- 1,054 vs. 6 +/- 5) in the patient group with PIGD as their predominant symptoms. Thus, the distinguishing feature of patients with severe PIGD appears to be a derangement in indoleamine metabolism at the reaction step catalyzed by aromatic amino acid decarboxylase (AADC). These findings suggest that aggravation of PIGD in advanced Parkinson's may be related in part to impaired serotonergic transmission secondary to inhibition or down regulation of AADC.

Duke Scholars

Published In

J Neural Transm (Vienna)

DOI

ISSN

0300-9564

Publication Date

1997

Volume

104

Issue

4-5

Start / End Page

451 / 459

Location

Austria

Related Subject Headings

  • Serotonin
  • Posture
  • Parkinson Disease
  • Osmolar Concentration
  • Neurology & Neurosurgery
  • Middle Aged
  • Indoles
  • Hydroxyindoleacetic Acid
  • Humans
  • Homovanillic Acid
 

Citation

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Iacono, R. P., Kuniyoshi, S. M., Ahlman, J. R., Zimmerman, G. J., Maeda, G., & Pearlstein, R. D. (1997). Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders. J Neural Transm (Vienna), 104(4–5), 451–459. https://doi.org/10.1007/BF01277663
Iacono, R. P., S. M. Kuniyoshi, J. R. Ahlman, G. J. Zimmerman, G. Maeda, and R. D. Pearlstein. “Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders.J Neural Transm (Vienna) 104, no. 4–5 (1997): 451–59. https://doi.org/10.1007/BF01277663.
Iacono RP, Kuniyoshi SM, Ahlman JR, Zimmerman GJ, Maeda G, Pearlstein RD. Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders. J Neural Transm (Vienna). 1997;104(4–5):451–9.
Iacono, R. P., et al. “Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders.J Neural Transm (Vienna), vol. 104, no. 4–5, 1997, pp. 451–59. Pubmed, doi:10.1007/BF01277663.
Iacono RP, Kuniyoshi SM, Ahlman JR, Zimmerman GJ, Maeda G, Pearlstein RD. Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders. J Neural Transm (Vienna). 1997;104(4–5):451–459.
Journal cover image

Published In

J Neural Transm (Vienna)

DOI

ISSN

0300-9564

Publication Date

1997

Volume

104

Issue

4-5

Start / End Page

451 / 459

Location

Austria

Related Subject Headings

  • Serotonin
  • Posture
  • Parkinson Disease
  • Osmolar Concentration
  • Neurology & Neurosurgery
  • Middle Aged
  • Indoles
  • Hydroxyindoleacetic Acid
  • Humans
  • Homovanillic Acid